Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Pearl Kogyo Co., Ltd.

Bbk Bio Corporation

The Hollenniun Laboratories

Meiryo Technica Corporation, Ltd.

The Mollennium Laboratories

Hiroyuki Arakawa

Susumu Satoh

Masahiko Morita

Mayako Yamazaki

Takao Isogai

Tetsuo Nishikawa

Toshio Ota

Shintaro Nishimura

Yuri Hio

Sousuke Miyoshi

Susumu Sato

Masafumi Koide

Jyunko Zenkou

Hiroshi Marusawa

Akiko Suzuki

Juichiro Nakashima

Yoshitaka Sakamoto

Masao Fukagawa

Yasuhiro Ogawa

Noriyuki Morikawa

Akiko Ohkubo

Takao Yamazaki

Yasuhiro Kita

Akiko Fujisawa Pharmaceutical Co Ltd Suzuki

Susumu Fujisawa Pharmaceutical Co Ltd Satoh

Juichiro The Mollennium Laboratories Nakashima

Sousuke Fujisawa Pharmaceutical Co Ltd Miyoshi

A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold gas plasma to thereby transfer the selected molecules located around cells into the cells, or cells are fused by treating the cells with cold gas plasma. Moreover, an apparatus for transferring selected molecules or fusing cells having a cold gas plasma generation unit for transferring selected molecules into cells is provided.

Method of transferring a selected molecule into a cell

The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these proteins were found to enhance cell damage. Compounds that can be screened based on the evaluation methods of this invention are useful as agents for inhibiting the CREB dephosphorylation reaction, agents for suppressing enhancement of cell damage, and preventive and therapeutic agents for memory disorders and/or neurodegenerative disorders.

Methods of evaluating phosphatase inhibitors

A molecule introducing apparatus is provided with a power supply circuitfor supplying power, a step-up transformerwhich is supplied with power from the power supply circuitand which outputs a high voltage, a switching transistorthat blocks off and allows the supply of power from the power supply circuitto the step-up transformerand which generates an instantaneous high voltage, and a pair of electrode probesfor applying the instantaneous high voltage generated at the step-up transformerto a predetermined region in a body. The molecule introducing apparatus oscillates DNA arranged outside a cell by the instantaneous high voltage so as to introduce the DNA into the cell.

Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method

The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-&#x3b2; protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-&#x3b2; protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-&#x3b2; protein.

Amyloid-&#x3b2; protein aggregation-regulating factors

Amyloid &#x3b2; protein agglutination-controlling factor

Growing community of inventors

Osaka, Japan

Hiroyuki Arakawa