Fujisawa Pharmaceutical Company, Ltd.

Hiroyoshi Sakai

Hisashi Takasugi

Atsushi Kuno

Takao Takaya

Yoshie Sugiyama

Kazuhiro Maeda

Kimio Esumi

Yoshie Sakamoto

Toshio Yamanaka

Masayuki Kato

Akito Tanaka

Mitsuru Ohkubo

Fumie Takahashi

Takatoshi Ishikawa

Beta-alanine derivative and a process for the preparation thereof

The present invention concerns glycoprotein IIa/IIIb antagonists and platelet aggregation inhibitors of the formula (I): ##STR1## wherein R.sup.1 is aryl which may have one or more suitable substituent(s),

Peptide compound and a process for the preparation thereof

The invention relates to cardioprotective compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2 R.sup.3 and R.sup.4 are moieties as described in the specification.

N-containing heterocyclic compounds, compositions and use

The invention relates to a pharmaceutical composition as a therapeutic agent for ischemic disease comprising a compound of the formula ##STR1## wherein R.sup.1 is carbamoyl substituted with morpholino (lower) alkyl, thiomorpholino(lower)alkyl or lower alkylamino(lower)alkyl; or ureido substituted with lower alkylamino(lower)alkyl; and

N-containing heterocyclic compounds, and composition comprising the same

The invention relates to diphenylpyridazine compounds useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl,

Di phenylpyridazine compounds, processes for the preparation thereof and

An N-containing heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted with hydroxy, halogen or a heterocyclic group, carboxy, esterified carboxy, carbamoyl optionally substituted with heterocyclic(lower)alkyl or lower alkylamino(lower)alkyl, N-containing heterocycliccarbonyl optionally substituted with lower alkyl, or ureido optionally substituted with lower alkylamino(lower)alkyl, and

Morpholine containing pyridine compounds, compositions and use

The invention relates to compounds for treatment of hypertension, and cardiovascular and cerebrovascular diseases, which compounds are of the formula: ##STR1## wherein R.sup.1 is piperazinyl(lower)alkyl, carbamoyl substituted with piperazinyl(lower)alkyl, or piperazinylcarbonyl, in each of which a piperazinyl group may be substituted with lower alkyl, and

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Uji, Japan

Hiroyoshi Sakai