Nippon Zoki Pharmaceutical Co., Ltd.

Agc Inc.

Hiroyoshi Nanba

Yoshitaka Nakazawa

Tomohiro Ookubo

Hiroyuki Yoshida

Ko Nakamura

Yasushi Matsumura

Arata Yasuda

Kazuyoshi Sawada

Kazuki Taguchi

Kenji Mitsuda

Teppei Seguchi

The present invention relates to a novel prostaglandin derivative having an alkynyl group on &#x3c9;-chain, particularly, a novel prostaglandin derivative having a double bond at the 2-position and an alkynyl group on the &#x3c9;-chain and a medicament containing the compound as an active ingredient. According to the present invention, a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof; 

Prostaglandin derivative

A cinnamic acid amide derivative having an excellent analgesic action is disclosed herein. The cinnamic acid amide derivative shows excellent analgesic actions to not only a nociceptive pain model animal, but also a neuropathic pain model animal, which is very useful as an agent for treating various pain diseases showing acute or chronic pains or neuropathic pains. The cinnamic acid amide derivative may be a compound represented by formula (I). 

Substituted cinnamic acid amides for treating pain

The amino acid derivative of the present invention provides a novel compound that shows excellent analgesic action. The amino acid derivative of the present invention is a novel compound that shows excellent analgesic action to not only a model animal for nociceptive pains but also a model animal for neuropathic pains, so that the amino acid derivative is very useful as a drug for treating various pain diseases.

Amino acid derivative

The present invention is to provide a novel compound which is useful as a pharmaceutical agent such as an analgesic. The present invention is to provide the novel histidine derivative having an excellent analgesic action and the like. The compound of the present invention has a very high intermigration into the blood upon oral administration and is very useful as a pharmaceutical agent, especially an analgesic for the treatment of acute or chronic pain diseases and of neuropathic pain diseases.

Histidine derivatives

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Kato, Japan

Hiroyoshi Nanba