Tanabe Seiyaku Company, Limited

Hiroyasu Seko

Eiji Takahashi

Masakatsu Furui

Takeji Shibatani

Yasuhiko Ozaki

Shinichi Yamada

Manabu Matsuoka

Disclosed is a process for preparing a D-amino acid selected from the group consisting of D-methionine, D-valine, D-leucine, D-isoleucine and D-histidine, which comprises the steps of:

Process for preparing D-amino acids

A process for preparing D-lysine using a microorganism which has the ability to asymmetrically degrade L-lysine in a reaction medium is disclosed. The process is performed by first bringing racemic lysine into contact with a culture or a treated culture of the microorganism, and then collecting and isolating the D-lysine from the reaction mixture.

Process for preparing D-lysine

Process for preparing optically active cis-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one compounds [I] of the formula: ##STR1## wherein Ring A and Ring B are substituted or unsubstituted benzene, R.sup.1 is hydrogen or di-lower alkylaminoalkyl, which comprises subjecting 1,5-benzothiazepin-4(5H)-one (II) of the formula [II]: ##STR2## wherein R.sup.4 is hydrogen or lower alkanoyl, and the other symbols are the same as defined above, to asymmetric reduction with a reaction product of optically active .alpha.-amino acid and metal hydride, in high optically yield, and said compounds [I] are very important as intermediate for preparing various medicines.

Process for preparing optically active benzothiazepine compounds by

Preparation of anisaldehyde by the oxidation of p-methoxytoluene in the vapor phase in the presence of a catalyst consisting of vanadium oxide, phosphorus oxide and potassium sulfate or a catalyst consisting of vanadium oxide, phosphorus oxide, potassium sulfate and copper oxide. The catalyst has excellent selectivity and, as a result, anisaldehyde is obtained in high yields. Further, the catalyst containing copper oxide has excellent durability.

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Nara, Japan

Hiroyasu Seko