Zenyaku Kogyo Kabushiki Kaisha

Hiroya Sasahara

Seiichiro Kawashima

Tetsuo Watanabe

Toshiyuki Matsuno

Shinichi Yaguchi

Toshiaki Suzuki

Kenichi Saito

Kenichi Saitoh

Yoshio Tsuchida

Sumio Terada

Toshihisa Kanda

Tsuneo Inoue

The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Rrepresents CHF(wherein n is 1 or 2), hydroxy C-Calkyl, NHR[wherein Rrepresents hydrogen atom or COR (wherein R represents hydrogen atom, C-Calkyl or C-Calkoxy)]; Rrepresents morpholino (which may be substituted with one to four C-Calkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C-Calkyl), oxazolidinyl (which may be substituted with one or two C-Calkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; Rand Reach represent hydrogen atom or C-Calkyl; and Rrepresents hydrogen atom, amino or hydroxyl.

Heterocyclic compound and antitumor agent containing the same as effective ingredient

The present invention relates to heterocyclic compounds represented by the formula I wherein X represents nitrogen atom or CH; Rrepresents halogen atom or hydroxyl; Rrepresents hydrogen atom, hydroxyl or amino; Rrepresents morpholino (which may be substituted with one or two C&#x2013;Calkyl), pyrrolidinyl (which may be substituted with hydroxy C&#x2013;Calkyl) or NRR[Rrepresents C&#x2013;Calkyl and Rrepresents piperidinyl (which may be substituted with C&#x2013;Calkyl)]; Rand Reach represents hydrogen atom or C&#x2013;Calkyl, with the proviso that Ris hydrogen atom and Ris pyrrolidinyl (which may be substituted with hydroxy C&#x2013;Calkyl) when Ris hydroxyl

Heterocyclic compounds and antitumor drugs containing the same as the active ingredient

The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components: wherein X represents nitrogen atom or CH; Rrepresents CHF(wherein n is 1 or 2), hydroxy C&#x2013;Calkyl, NHR[wherein Rrepresents hydrogen atom or COR (wherein R represents hydrogen atom, C&#x2013;Calkyl or C&#x2013;Calkoxy)]; Rrepresents morpholino (which may be substituted with one to four C&#x2013;Calkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C&#x2013;Calkyl), oxazolidinyl (which may be substituted with one or two C&#x2013;Calkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; Rand Reach represent hydrogen atom or C&#x2013;Calkyl; and Rrepresents hydrogen atom, amino or hydroxyl.

Heterocyclic compound and antitumor agent containing the same as active ingredient

Quinoline sulfide derivatives

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Tokyo, Japan

Hiroya Sasahara