Fuso Pharmaceutical Industries, Ltd.

Other

Fuso Pharmaceuticals, Ltd.

Tsuneya Ohno

Hirotsugu Uehara

Akio Matsuhisa

Soji Eda

Masahiro Asakura

Hiroyuki Keshi

Kanako Abe

Yuichi Oku

Hiroshi Ueyama

Souji Eda

Yoshihiko Uesaka

Shiho Yamazaki

Nana Sakamoto

Aya Keshi

Yusuke Shibahara

Keigo Nishida

Kazumasa Kamei

Norihiko Sugimoto

Very simple, highly sensitive detection or quantification of target nucleic acids of interest has been achieved by: hybridizing mask oligonucleotides to regions in a single-stranded region of a nucleic acid to be assayed between which a region to be hybridized by an oligonucleotide probe is positioned, thereby opening the probe-hybridizing region and keeping the single-stranded region of the target nucleic acid stable, and then subjecting this nucleic acid having the single-stranded region to nucleic acid chromatography.

Nucleic acid detection or quantification method using mask oligonucleotide, and device for same

The present invention provides antibodies that show specific reactivity to disulfide-type HMGB1. Furthermore, the present invention provides methods for specifically measuring disulfide-type HMGB1 using the antibodies, and kits or reagents for the measurement. The present invention also provides methods for measuring total HMGB1 using such an antibody and an antibody that binds to both disulfide-type HMGB1 and reduced-type HMGB1 but does not bind to des-HMGB1, and kits or reagents for the measurement.

Disulfide-type HMGB1-specific antibody, method for measuring disulfide-type HMGB1 and kit for said measurement, and measurement method capable of quantitating all of HMGB1 molecules including reduced HMGB1, disulfide-type HMGB1 and thrombin-cleavable HMGB1 and kit for said measurement

A probe derived from bacteria of pneumonia, containing fragments of DNA which essentially possesses, and useful for detecting and identifying causative bacteria of pneumonia is obtained by completely digesting the DNA with a restriction endonuclease PstI, followed by cloning into a suitable vector.

Probe for diagnosing infectious diseases

DNA probes for detecting the presence of,are provided. These isolated, purified oligonucleotide probes are useful in assays for the specific detection of,because they specifically hybridize to the DNA of

Probes for detecting and identifying Helicobacter pylori

DNA probes for diagnosing infectious diseases involving Enterococcus faecalis and methods of using such probes are provided.

Probe for diagnosing Enterococcus faecalis

Probe for diagnosing infectious disease

DNA probes for diagnosing infectious diseases involving Pseudomonas aeruginosa and methods of using such probes are provided.

Probe for diagnosing Pseudomonas aeruginosa

DNA probes for diagnosing infectious diseases involving Staphylococcus epidermidis and methods of using such probes are provided.

Probe for diagnosing staphylococcus epidermidis

DNA probes for diagnosing infectious diseases involving Escherichia coli, Klebsielkli pneunmoniae or Enterobacter cloacae and methods of using such probes are provided.

Growing community of inventors

Kobe, Japan

Hirotsugu Uehara