Japan Tobacco Inc.

Hirotsugu Ito

Takahisa Motomura

Koichi Suzawa

Hisashi Shinkai

Hironobu Nagamori

Satoru Kobayashi

Toru Morita

Hiroshi Yamamoto

Takuya Matsuo

Takashi Inaba

Takahiro Yamasaki

Masafumi Inoue

Takao Ito

Tsubasa Takeichi

Yasuyuki Kajimoto

Yukishige Ikemoto

A production method of a compound represented by the formula [I]: or a pharmaceutically acceptable salt thereof, or a hydrate thereof.

Production method for pyrazole-amide compound

The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.

Fluorene compound and pharmaceutical use thereof

Growing community of inventors

Takatsuki, Japan

Hirotsugu Ito