Passport Technologies, Inc.

Hirotoshi Adachi

Masato Nishimura

Shohei Horie

Joe Hua

Akinori Hanatani

Yuki Yamada

To provide a transdermal drug delivery patch that can be suitably used for an immediate release application of a pharmaceutical with a comparatively low molecular weight. A transdermal drug delivery patch, provided with a matrix and at least one drug disposed within the matrix, wherein the matrix has a water holding capacity of 10 mg/cmor less, and the drug is a pharmaceutical having a molecular weight of 5000 or less.

Transdermal drug delivery patch, drug delivery system and drug delivery

A transdermal delivery system for delivery of a triptan into a tissue membrane of a subject. The system includes a transdermal microporation apparatus for heating a skin surface and a triptan drug delivery patch. The drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising the triptan, and a bottom layer. A method for treating a subject comprises identifying a subject having a migraine, using the transdermal microporation apparatus to open a plurality of micropores in the skin of the subject, and applying the triptan drug delivery patch to the subject's skin over the micropores for a period of time effective to deliver the triptan through the micropores in an amount effective to treat the subject's migraine.

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San Diego, CA, United States of America

Hirotoshi Adachi