Passport Technologies, Inc.

Hirotoshi Adachi

Joe Hua

Masato Nishimura

Shohei Horie

Akinori Hanatani

Yuki Yamada

Gregg Robert Draudt

Uros Kascak

William J Vespa

Masahiro Mitsushima

Harshal Shah

Kaitlyn Delaney Mary Leidl

Karen Unterman

Amy Lee Stockslager

Arjun Singh Bhungal

Megha Chaudhary Sharma

Systems and methods for controlling energy delivered for thermal ablation. An apparatus may include a conductive member comprising an array of conductive filaments, a power supply configured to provide the current to the conductive/resistive member in a plurality of electrical pulses, and a processing circuit coupled to the power supply. The processing circuit is configured to control the supply current value to be greater than or equal to a first current density and less than or equal to a second current density, and control the pulse length to be greater than or equal to a first pulse length and less than a second pulse length, control the supply current value to have a third current density at a first time and a fourth current density at a second time.

Methods and systems for controlling energy delivery to filament devices

Transdermal applicator

To provide a transdermal drug delivery patch that can be suitably used for an immediate release application of a pharmaceutical with a comparatively low molecular weight. A transdermal drug delivery patch, provided with a matrix and at least one drug disposed within the matrix, wherein the matrix has a water holding capacity of 10 mg/cmor less, and the drug is a pharmaceutical having a molecular weight of 5000 or less.

Transdermal drug delivery patch, drug delivery system and drug delivery

A transdermal delivery system for delivery of a triptan into a tissue membrane of a subject. The system includes a transdermal microporation apparatus for heating a skin surface and a triptan drug delivery patch. The drug delivery patch comprises a top layer comprising an adhesive, a middle layer comprising the triptan, and a bottom layer. A method for treating a subject comprises identifying a subject having a migraine, using the transdermal microporation apparatus to open a plurality of micropores in the skin of the subject, and applying the triptan drug delivery patch to the subject's skin over the micropores for a period of time effective to deliver the triptan through the micropores in an amount effective to treat the subject's migraine.

Triptan microporation delivery system

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San Diego, CA, United States of America

Hirotoshi Adachi