Hisamitsu Pharmaceutical Company, Inc.

Kyodo Printing Co., Ltd.

Hirotoshi Adachi

Naruhito Higo

Seiji Tokumoto

Kazutaka Inoue

Hiroyuki Maeda

Tatsuya Ogawa

Tetsuji Kuwahara

Yasushi Fuchita

Kazuya Katagai

Tatsuya Meno

Hitoshi Otomo

Noriyuki Kuzumaki

Tetsuya Arimoto

An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein Rand Rmay together form a cyclic ring, and Rand Rindependently represent an alkyl side chain having 1 to 16 carbon atoms. 

Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration

An iontophoresis device activated in use, which is capable of supplying a dissolution liquid in an amount that depends on the amount of a drug when it is used, is provided. This iontophoresis device activated in use comprises: an absorberformed of a material containing a dry drugand capable of absorbing a liquid; a wall materialdisposed around the absorber, having an adhesive layeron the undersurface thereof; a supportdisposed on the absorberand the wall material, having an openingin the central portion thereof; an electrodedisposed on the undersurface of the support; a diaphragmdisposed on the support; and a dissolution liquid reservoirdisposed on the diaphragm, retaining a dissolution liquid for dissolving the drug between the diaphragmand itself, and having a protruding portionfor destroying the diaphragmby pressing force. The protruding portionhas a linear apical portion, for example, and it is disposed so that it is allowed to come into contact with or is close to the diaphragm. A lineris removably attached on the undersurface of both the absorberand the adhesive layer

Iontophoresis device activated in use

Device structurefor iontophoresis provides electrodeand electrically conductive layer. Electrically conductive layercontains active ingredient D and basic water swelling methacrylate copolymer Pand/or acidic water swelling methacrylate copolymer P. Electrodeand electrically conductive layerare placed into a hollow of backingand electrode terminalis connected to electrodethrough backing. Adhesive layeris set around backing, and linerto be removed when using the device, is placed so as to cover the hollow of backing

Composition and device structure for iontophoresis

A device for iontophoresis that reduces irritation at the beginning of energization and efficiently supplies an amount of current required for drug administration in a predetermined length of time, is provided. With the device for iontophoresis, the oscillation frequency and duty cycle of a transistorare adjusted at the beginning of energization, thereby controlling a back electromotive force developed across a coilto gradually increase the output voltage. The microcomputercontrols the transistorso as to receive signals from an output voltage detecting circuit that is formed of resistorsandand an output current detecting circuit that is formed of resistorsandand a capacitor, preventing an increasing of the output voltage when the detected output current reaches a limiting value, and preventing an increasing of the output current when the detected output voltage reaches a limiting value.

Device for iontophoresis

It is intended to provide an interface for a transdermal drug administration device that can supply a drug almost evenly and favorably from a plurality of projections through skin. This interface for a transdermal drug administration device has a flat plate. The flat platecomprises a plurality of two-dimensionally arranged conical or pyramidal projectionscapable of piercing skin and a plurality of openingscapable of delivering a drug which are respectively arranged in correspondence with the projections. The openingsare respectively arranged in proximity to their corresponding projections. The flat platecan be made of a metal or ceramics. The ratio between the number of the openings and the number of the projections can be 1:1 to 1:2.

Interface for transdermal drug administration device

The invention provides a device for a percutaneous absorption preparation, provided with a solution storage container which can exhibit good solution migration independently of the level of force. The device for a percutaneous absorption preparation comprises an electrode film comprising a base member () and an electrode layer () and having a dissolution liquid passage hole (), a drug impregnation member () mounted on the electrode layer () side of the electrode film, and a dissolution liquid storage container () bonded to the base member () side of the electrode film via a lid member () covering the solution passage hole (). The dissolution liquid storage container () comprises a bottom and a sidewall. A protrusion () which faces the dissolution liquid passage hole () is provided at the center of the bottom, and the sidewall is provided with a vertically folded part ().

Device for percutaneous absorption preparation

The present invention provides an iontophoresis device and an energization method whereby a prostaglandin can be effectively and continuously administered via a skin or mucosa. The iontophoresis device comprises the first electrode structure ( ); the second electrode structure ( ); and a power supply ( ) electrically connected between the first and the second electrode structures ( ), ( ). At least one of the first and the second electrode structures contains a prostaglandin and also stabilizing means for inhibiting hydrolysis of the prostaglandin during storage. The power supply ( ) is equipped with constant current supplying means and, when both electrode structures contain a prostaglandin, also polarity inverting means. Output current from the power supply may allow the prostaglandin to be delivered to a skin or mucosa.

Iontophoresis device

A handling-convenient device for iontophoresis, which can supply spotted regions suffering from disease with a proper quantity of current at the same time. The device for iontophoresis includes a power source apparatus having a plurality of output terminals outputting currents of predetermined values adjusted by a plurality of current control circuits, respectively, and a plurality of connecting cords, each cord being connected with one of the output terminals of the power source apparatus at one end thereof and being connected with an electrode structure at the other end. The connecting cords are attached with the power source apparatus in a mutually attachable/detachable fashion via connection terminals. The power source apparatus has an LED located thereon to notify of the energization status of the device and a power switch externally located thereon to control starts and stops of the apparatus.

Device for Iontophoresis

An iontophoretic device structure of the dissolution-on-use type is provided, wherein an ionized drug is transdermally or transmucosally administered into a living body. The device structure comprises (a) a non-polarizable electrode, (b) a hydrophilic, polymeric gel layer containing an ion exchange resin which is able to specifically inhibit the movement of ions dissolved out from the electrode while in use, and (c) a drug layer containing a drug in a dry condition in a drug retaining membrane, wherein when said device is in use, said drug layer is brought into contact with said hydrophilic, polymeric gel layer so that said drug in the dry condition is dissolved. A humectant may be contained in the hydrophilic, polymeric gel layer and/or the drug layer.

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Tsukuba, Japan

Hirotoshi Adachi