Hokkaido University

Nof Corporation

Taiho Pharmaceutical Company Limited

Hiroto Hatakeyama

Hideyoshi Harashima

Hidetaka Akita

Kazuhiro Kubo

Kota Tange

Masaya Arai

Yuta Nakai

Yusuke Sato

Hiroki Tanaka

Takashi Nakamura

Masaki Ota

Kenji Kusumoto

Shota Sasaki

Mamoru Hyodo

Masami Ukawa

Shota Warashina

Taichi Ishitsuka

Yuki Noguchi

Nayuta Shimizu

Ryohei Ishiba

A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (Rand Rrepresent CH&#x2014;(CH)&#x2014;CH&#x2550;CH&#x2014;CH&#x2014;CH&#x2550;CH&#x2014;(CH)&#x2014;, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and Rand Rrepresent a Calkyl group or a Calkenyl group.

Lipid membrane structure for intracellular delivery of siRNA

The invention provides a cationic lipid capable of achieving higher intracellular delivery efficiency than conventional cationic lipids, when used as a lipid membrane structure which is a carrier for delivering functional nucleic acid. The cationic lipid is represented by the formula (1): 

Cationic lipid for nucleic acid delivery

The present invention relates to a compound represented by the formula (1) wherein Xand Xare each independently Xor X; s is 1 or 2,Ris an alkyl group having 1-6 carbon atoms,nand nare each independently 0 or 1,Rand Rare each independently an alkylene group having 1-6 carbon atoms,Rand Rare each independently an alkylene group having 1-6 carbon atoms,Yand Yare each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, andRand Rare each independently a sterol residue, a liposoluble vitamin residue or an aliphatic hydrocarbon group having 12-22 carbon atoms,and use thereof.

Cationic lipid having improved intracellular kinetics

The present invention provides a liposome having excellent lung migration ability that had not existed hitherto, by including GALA or Chol-GALA in the liposome. Furthermore, by using the liposome, a pulmonary delivery carrier having a stronger knockdown effect of siRNA when compared to existing carriers is provided.

Vector for pulmonary delivery, inducing agent, and uses

Growing community of inventors

Sapporo, Japan

Hiroto Hatakeyama