Bonac Corporation

Hirotake Hayashi

Tadaaki Ohgi

Tomohiro Hamasaki

Hiroshi Suzuki

Akihiro Itoh

Hisao Shirohzu

Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton

Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5' side to the 3&#x2032; side: a 5&#x2032; side region (Xc); an inner region (Z); and a 3&#x2032; side region (Yc). The inner region (Z) is composed of an inner 5&#x2032; side region (X) and an inner 3&#x2032; side region (Y) that are linked to each other. The 5&#x2032; side region (Xc) is complementary to the inner 5&#x2032; side region (X). The 3&#x2032; side region (Yc) is complementary to the inner 3&#x2032; side region (Y). At least one of the inner region (Z), the 5&#x2032; side region (Xc), and the 3&#x2032; side region (Yc) includes the expression inhibitory sequence.

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Fukuoka, Japan

Hirotake Hayashi