Chugai Seiyaku Kabushiki Kaisha

Hirotaka Kashiwagi

Nobuyuki Hori

Satoshi Tsuchiya

Yoshiyuki Ono

Masahiro Nishimoto

Atsushi Matsuo

Yoshikazu Nishimura

Masahide Aoki

Satoshi Tanida

Takuma Kamon

Hiroko Ogawa

Takahiro Kawai

Kyoko Oguri

Shoshin Yoshida

Tsutomu Sato

Hitoshi Yoshino

Yoshiyuki Furuta

Takuya Shiraishi

David Mark Wallace

Yoshiaki Watanabe

Mi Chen

Jie Fei Cheng

Thomas Arrhenius

Sovouthy Tith

Naoki Okamoto

Atsushi Kimbara

Kenichi Nomura

Eisaku Mizuguchi

Tadakatsu Takahashi

Tsuyoshi Haneishi

Kazutaka Tachibana

Kazuki Shimizu

Yoshihito Ohtake

Shota Tanaka

Yoshihisa Murata

Takeo Harada

Shuichi Ohtomo

Yasuhiro Ichida

Mitsuaki Ide

Naoshi Horiba

The present invention provides a compound having the basic structure shown by Formula (I) in which the indole ring and the pyrazolopyridine structure is bound through a substituent, a salt thereof or a solvate of either the compound or a salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound, salt or solvate as an active ingredient.

Pyrazolopyridine derivative having GLP-1 receptor agonist effect

The present invention provides the compound, 3-[(1S,2S)-1-[5-[(4S)-2,2-Dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a pharmaceutically acceptable salt of the compound, as well as a preventative agent or a therapeutic agent for non-insulin-dependent diabetes mellitus (Type 2 diabetes) or obesity containing such compound.

The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

Dihydropyridazine-3,5-dione derivative and pharmaceuticals containing the same

An object of the present invention is to provide a process for synthesizing a vitamin D compound by simple procedures at lower costs. The present invention provides a process for preparing a vitamin D compound and an intermediate thereof, comprising the step of: (a) mixing a ketone or aldehyde, a Wittig reagent, and a base; or (b) mixing a ketone or aldehyde and a Wittig reagent, and then adding a base to the resulting mixture.

Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds

Novel compounds composition capable of inhibiting TNF&#x3b1; and having antiimmunionflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.

Coumarin derivatives useful as TNF&#x3b1; inhibitors

The present invention provides a compound represented by the following general formula (I): or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a compound, and the like. The compound or a pharmaceutically acceptable salt thereof, the pharmaceutical composition containing such a compound, or the like is useful as a medicine or the like for therapy of benign prostatic hyperplasia, cancer, osteoporosis, psoriasis, secondary hyperparathyroidism, chronic glomerulonephritis, lupus nephritis and/or diabetic nephropathy and the like.

Vitamin D-like compound

Novel compounds composition capable of inhibiting TNF&#x3b1; and having antiimmunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds.

Novel compounds composition capable of inhibiting TNF&#x3b1; and having anti immunoinflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these novel compounds. 

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Shizuoka, Japan

Hirotaka Kashiwagi