Fujifilm Corporation

Chugai Seiyaku Kabushiki Kaisha

Other

Perseus Proteomics Inc.

Mitsubishi Cable Industries, Ltd.

Japan Display Inc.

The University of Tokyo

Aburatani, Hiroyuki

Hirotaka Ito

Hiroyuki Aburatani

Toshihiko Ohtomo

Yukio Ito

Yoshitaka Hippo

Hirokazu Taniguchi

Shogo Yamamoto

Shumpei Ishikawa

Yong Xin Chen

Shin-ichi Fukumoto

Takahiro Shimamura

Ying Qiu Guo

Kenji Yoshida

Akira Watanabe

Masahiro Arai

Yasuko Kinoshita

Naoko Kamimura

Masayuki Tsuchiya

Hiromichi Tanaka

Sho Onozawa

Kaoru Inoue

Shigeto Kawai

Kiyotaka Nakano

Shin-Ichi Funahashi

Masashi Fukayama

Masaru Nakamura

Shinichi Watabe

Takeshi Unemura

Mikiyoshi Saito

Shunpei Ishikawa

Tokuzo Sukegawa

Naoka Kamimura

Shin-ichi Funahshi

Shin-ichi Funahashi

Motooki Ashihara

Shin-Ichi Fukumoto

A processor analyzes an image obtained by imaging a subject including a tubular structure in which a fluid flows, thereby deriving fluid information regarding flow of the fluid at each of pixel positions in the tubular structure. The processor derives, within the tubular structure included in the image, a matching degree between the fluid information at a plurality of pixel-of-interest positions set at a first sampling interval and the fluid information at a plurality of pixel positions within a predetermined region based on the pixel-of-interest positions. The processor sets a second sampling interval for displaying the fluid information in accordance with the matching degree. The processor samples the fluid information at the set second sampling interval and causes a display to display the fluid information.

Fluid analysis apparatus, fluid analysis method, and fluid analysis program

A processor analyzes an image obtained by imaging a subject including a tubular structure in which a fluid flows, thereby deriving fluid information regarding flow of the fluid at each of pixel positions in the tubular structure. The processor sets a sampling interval for displaying the fluid information in accordance with a size of a region intersecting a center line of the tubular structure included in the image. The processor samples the fluid information at the set sampling interval and causes a display to display the fluid information.

An image acquisition unit acquires a phase contrast image consisting of a plurality of phases for each of three spatial directions, in which a pixel value of each pixel represents a velocity of fluid for each of the three directions, the phase contrast image being acquired by imaging a subject including a structure inside which fluid flows by a three-dimensional cine phase contrast magnetic resonance method. An identification unit identifies a region of the structure in the phase contrast image on the basis of a maximum value of the velocity of the fluid between corresponding pixels in each of the phases of the phase contrast image.

Region identification device, region identification method, and region identification program

The invention provides a fluid analysis apparatus, a method for operating a fluid analysis apparatus, and a fluid analysis program that display a flow velocity vector such that the tendency of a fluid flow is easily checked. A representative two-dimensional flow velocity vector representing a plurality of two-dimensional flow velocity vectors obtained by projecting three-dimensional flow velocity vectors of a plurality of voxels that overlap each other in a projection direction of a projection plane to the projection plane is acquired from three-dimensional volume data that has information of the three-dimensional flow velocity vector indicating the flow velocity of a fluid in an anatomical structure for each voxel and is displayed.

Fluid analysis apparatus, method for operating fluid analysis apparatus, and fluid analysis program

The invention provides a fluid analysis apparatus, a method for operating a fluid analysis apparatus, and a fluid analysis program that perform display such that the tendency of a fluid flow in a blood vessel is easily checked. Route position information that is capable of identifying an order along a route of the anatomical structure is assigned to each position in the anatomical structure, using three-dimensional volume data in which each voxel has the information of a three-dimensional flow velocity vector indicating a flow velocity of a fluid in an anatomical structure. The three-dimensional flow velocity vector is selected such that the route position information of a position where the three-dimensional flow velocity vector is present is sequentially arranged from one point in the anatomical structure and a trajectory indicating the flow of the fluid is drawn so as to be visibly recognized.

The blood flow analysis apparatus includes a blood vessel region extraction unit that extracts a blood vessel region from a blood vessel image obtained by capturing an image of an object including a blood vessel; a flow velocity vector acquisition unit that acquires a flow velocity vector indicating a blood flow velocity and a blood flow direction in the blood vessel region; and a back flow specification unit that sets a central axis which extends in an extension direction of the blood vessel region, integrates a component of the flow velocity vector in a direction of the central axis with respect to a time axis to calculate an integral value, and specifies whether there is a blood back flow in the blood vessel region on the basis of a change in the integral value.

Blood flow analysis apparatus, blood flow analysis method, and blood flow analysis program

Performance of a display apparatus is improved. The display apparatus includes: a substrate having a side surface (first side surface); a backlight unit (light supply portion) having a side surface (second side surface); a flexible wiring board having a wiring electrically connected to a terminal (first terminal) and having an insulating film with flexibility covering the wiring; and a double-sided tape. The flexible wiring board is bonded to the side surface of the backlight unit through the double-sided tape.

Display apparatus

A three-dimensional image projection apparatus includes: a screen recognition unitthat recognizes a position of a screen which is randomly provided and a posture of the screen in a three-dimensional space; a projection unitthat projects a projection image of a three-dimensional image of a subject on the screen on the basis of the position of the screen recognized by the screen recognition unit; and a three-dimensional image processing unitthat changes parameters of three-dimensional image processing performed for the three-dimensional image, on the basis of the posture of the screen in the three-dimensional space which is recognized by the screen recognition unit

Three-dimensional image projection apparatus, three-dimensional image projection method, and three-dimensional image projection control program

Methods that involve detection of a DSG3 protein for diagnosing cancer are disclosed. In lung cancer, the expression of DSG3 was found to be enhanced at very high frequency at the gene level and protein level. Methods of the present invention can be carried out using an antibody that recognizes a DSG3 protein. Pharmaceutical compositions, cell growth inhibitors, and anticancer agents containing a DSG3-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in DSG3-expressing cells and methods of suppressing proliferation of DSG3-expressing cells by contacting the DSG3-expressing cells with DSG3-binding antibodies are also disclosed.

Diagnosis and treatment of cancer using anti-desmoglein-3 antibodies

A blood flow analysis device includes a blood vessel region extraction unit that extracts a blood vessel region from a three-dimensional medical image of a subject including a blood vessel, and a blood flow simulation unit that obtains a line resistance by multiplying a resistance value corresponding to a branch blood vessel branching out of the blood vessel region by a surface area of each of preset sections into which the blood vessel region is divided in an extension direction, generates a vascular network model by applying the line resistance to each node of a surface of the blood vessel region, and performs simulation of a blood flow by using the vascular network model.

Blood flow analysis device, method, and program

A first registration unit performs first registration between a live view and an associated image associated with an object to be imaged. A second registration unit performs second registration between the object captured in the live view and the associated image based on the result of the first registration. At least while the second registration is performed, a display control unit superimposes the associated image on the object captured in the live view, and displays an enlarged view of a partial region of the live view, on which the associated image is superimposed. The second registration unit performs the second registration using a region of the live view larger than the partial region while the enlarged view of the partial region of the live view is displayed.

Device and method for image registration, and a nontransitory recording medium

There is provided an image registration device, method, and program that enable easy and quick initial registration between a target part included in an intraoperative video and simulation information, such as a simulation image. A first registration unit performs initial registration between an intraoperative video and simulation information. At this time, an intraoperative image for registration in an intraoperative video is displayed on a display. An operator performs registration between a target part included in the intraoperative image and the simulation information. After the end of initial registration, a second registration unit performs second registration between the simulation information and the target part included in the intraoperative video based on the result of the initial registration.

Image alignment device, method, and program

The present inventors identified inhibition of a combination of EGFR ligands that serve as targets for inhibition of cancer cell proliferation. More specifically, EREG antagonists and TGF&#x3b1; antagonists were found to be useful as inhibitors of cell growth. The present invention relates to pharmaceutical compositions containing EGF family ligand antagonists as components.

Method for treating a disease originated from receptor activation by EREG and TGF&#x3b1;

A method for diagnosing cancer comprising detecting ROBO1 protein is disclosed. In addition, a method for treating a disease caused by abnormal cell growth comprising administrating an antibody that binds to ROBO1, as well as a pharmaceutical composition, a cell growth inhibitor and an anticancer agent comprising an antibody that binds to ROBO1 as an active ingredient are disclosed. Further, a method for inducing cell damages in a ROBO1 expressing cell and a method for inhibiting the growth of a ROBO1 expressing cell by bringing a ROBO1 expressing cell into contact with an antibody that binds to ROBO1, are disclosed. Furthermore, a method for monitoring progression of hepatitis by detecting ROBO1 protein is disclosed.

Cancer diagnosis and treatment of cancer using anti-ROBO1 antibody

Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a nucleotide sequence complementary thereto. The gene and the protein of the invention is useful for diagnosing and treating cancer.

Growing community of inventors

Tokyo, Japan

Hirotaka Ito