Yoshitomi Pharmaceutical Industries, Ltd.

Hiroshi Yuki

Michio Terasawa

Michio Nakanishi

Tomonori Imayoshi

Hiroyuki Sueoka

Mitsuyoshi Yasumoto

Purine derivative and pharmaceutical composition

Substituted pyrrolidinemethanols of the formula: ##SPC1## Wherein R.sup.1 and R.sup.2 are each H or C.sub.1.sub.-4 alkyl; R.sup.3, R.sup.4 and R.sup.5 are each H, halogen, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy, or R.sup.3 and R.sup.4 combinedly form methylenedioxy; and R is C.sub.1.sub.-10 alkyl or a group of the formula: ##SPC2## Where R.sup.6, R.sup.7 and R.sup.8 are each H, halogen, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy, or R.sup.6 and R.sup.7 combinedly form methylenedioxy; and pharmaceutically acceptable acid addition salts thereof are disclosed. They are useful as drugs for the treatment of diseases of the heart and circulation.

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Nakatsu, Japan

Hiroshi Yuki