Takeda Pharmaceutical Company Limited

Public University Corporation Yokohama City University

Hiroshi Yoshikawa

Masahiko Kato

Yuusuke Sakurai

Jotaro Kishimoto

The present invention inhibits the occurrence of the foreign matters attributable to an adhesive for bonding an injection needle to a needle-base member so as to enhance the yield of a syringe when producing the same. A front-assembly () additionally provided at a leading end of an injection cylinder () comprises an injection needle (), a needle-base member (), a connection hub () and a protector cap (). The injection needle () and the needle-base member () are fixed to each other with an epoxy adhesive (). This adhesive () contains denatured aliphatic epoxy resin in the amount set to about 10 to about 25 wt % and its viscosity is set to about 20000 to about 40000 mPa&#xb7;s. This adhesive () is heated at a temperature of at least 130 degrees C. for about 20 minutes to cure it. After the front-assembly () and the injection cylinder () have been sterilized with vapor, the connection hub () has a connection portion () external fitted and secured to the leading end of the injection cylinder ().

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Osaka, Japan

Hiroshi Yoshikawa