Tanabe Seiyaku Company, Limited

Hiroshi Wada

Taku Nagao

Hideo Nakai

Hajime Tamaki

Hideo Yabana

Masaaki Matsuo

Mikio Takeda

Takashi Ochiai

Masaru Inage

Masatoshi Kawamori

Mikio Matsumoto

Nobuchika Tsumagari

Kazuhiro Ishii

Yuichi Onoda

This invention relates to imidazolidinone compounds of the formula ##STR1## wherein Q is methylene group or a single bond:

Imidazolidinones as brain activators

A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, R.sup.2 is hydrogen or a lower alkyl group, R.sup.3 is hydrogen, a lower alkyl group or a lower alkanoyl group, Q is a single bond or a lower alkylene group, Alk is a lower alkylene group, Y and Z are the same or different and are oxygen atom or sulfur atom and the group of the formula: ##STR2## is either ##STR3## or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.

Thiazolidine derivatives

A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, Q is a single bond, a lower alkylene group or a lower alkenylene group, R.sup.2 and R.sup.3 are the same or different and each is hydrogen atom, a lower alkyl group, a cycloalkyl group, a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkylsulfonyl group, a benzoyl group, a phenyl group or a di(lower alkyl)phosphoryl group, Alk is a lower alkylene group, and Y and Z are the same or different and each is oxygen atom or sulfur atom, or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.

N-substituted-2-[2-[2-(4-p

A naphthalene derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is lower alkyl or phenyl-lower alkyl; or R.sup.1 and R.sup.2 are combined together to form lower alkylene; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration, and a method of preparation thereof are disclosed. Said naphthalene derivative is useful as a chiral reagent for determining the optical purity of an optically active compound containing within its molecule at least one functional group selected from hydroxy, amino and imino groups.

Naphthalene derivatives and method for preparation thereof

A method for the therapeutic treatment and/or prophylaxis of gastro-intestinal diseases using a sulfodehydroabietic acid of the formula: ##STR1## or a pharmaceutically acceptable salt thereof is disclosed.

Method for treatment or prophylaxis of gastro-intestinal disease

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Omiya, Japan

Hiroshi Wada