Suntory Limited

Asubio Pharma Co. Ltd.

Hiroshi Uramoto

Hirokazu Annoura

Naohiro Takemoto

There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R, R, Rand Rare, independent from each other, alkoxy group, alkyl group or aryl group, etc.; Eand Eare oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is phenyl group which may be substituted or benzoyl group, etc, or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca-binding proteins.

Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof

There is provided an aminophenoxyacetic acid derivative of the following formula (I):wherein, R, R, Rand Rare, independent from each other, alkoxy group, alkyl group or aryl group, etc.; Eand Eare oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is pheny group which may be substituted or benzoyl group, etc,or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca-binding proteins.

Growing community of inventors

Osaka, Japan

Hiroshi Uramoto