Kyowa Hakko Kirin Co., Limited

Kyowa Hakko Kogyo Co., Ltd.

Hiroshi Umehara

Yutaka Kanda

Yoshinori Yamashita

Tomoyuki Nishikawa

Yoshisuke Nakasato

Yukimasa Shiotsu

Tomoki Naoe

Hitoshi Kiyoi

Fumihiko Kanai

Shinji Nara

Yoshihisa Ohta

Motoki Miyama

Keiko Kawashima

Hiromi Ando

Hitoshi Arai

Tsutomu Matsumura

Hiroshi Ishida

Koji Hagihara

Hajime Kashima

Syoichi Isami

Nana Oiwa

Yusuke Yamada

Toshihiro Seike

The present invention provides an antitumor agent and the like, which comprises as an active ingredient, a pyrimidine derivative represented by Formula (I): [wherein &#x2014;X&#x2014;Y&#x2014;Z&#x2014; represents &#x2014;O&#x2014;CR&#x2550;N&#x2014; (wherein Rrepresents a hydrogen atom, a substituted or unsubstituted aromatic heterocyclic group and the like) and the like, Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like) and the like, Rrepresents &#x2014;NRR(wherein Rand Rmay be the same or different, and each represents a hydrogen atom, substituted or unsubstituted lower alkyl and the like)] or a pharmaceutically acceptable salt thereof.

Pyrimidine derivative compound

The present invention provides a compound represented by Formula (I): [wherein Rrepresents CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like,Rrepresents a hydrogen atom, CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].

Indazole derivatives

The present invention provides a compound represented by Formula (I): [wherein Rrepresents CONRR(wherein Rand Rmay be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or Rand Rare combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like,

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Sunto-gun, Japan

Hiroshi Umehara