Fujisawa Pharmaceutical Company, Ltd.

Hiroshi Terano

Masanobu Kohsaka

Masashi Hashimoto

Shigehiro Takase

Morita Iwami

Michio Yamashita

Yasuhisa Tsurumi

Itsuo Uchida

Tadaaki Komori

Masakuni Okuhara

Yasuhiro Hori

Sumio Kiyoto

Hiroyuki Setoi

Toshio Goto

Motohiro Hino

Motoaki Nishikawa

Hidetsugu Murai

Takanao Otsuka

Hidenori Nakajima

Koen Verhaeghe

Toshihiro Shibata

WB2663 substance-producing bacteria belonging to the genus Pseudomonas are cultured to produce a physiologically active substance, from which are isolated neutral substances WB2663A, WB2663B and WB2663C having respective specific rotations

WB2663 substances and method for their production

This invention relates to new compounds WF 2015 A and B which have immunosuppressing activity and antitumor activity, to a process for producing WF 2015 A and B by culturing a WF 2015 A and/or B-producing strain belonging to the genus Scolecobasidium in a nutrient medium, and to a pharmaceutical composition comprising the same.

New compounds WF 2015 A and B

The invention relates to a method for treatment of carcinoma or sarcoma tumor in mammals which comprises administering to said mammal an effective amount of a tetracyclo compound of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy, aryliminomethyl, hydroxyiminomethyl, alkoxyiminomethyl, acyloxyiminomethyl, semicarbazonomethyl or arylsemicarbazonomethyl,

Method of treating tumors using tetracyclo compounds

Novel compounds of the following formula have restorative pharmacological activities in immuno-deficient hosts, ##STR1## wherein R.sup.1 is amino or a protected amino group,

Amino acid derivatives and processes for preparation thereof

A biologically pure culture of Streptomyces sandaensis which is capable of producing an antitumor and antimicrobial compound, designated FR-900482 substance, is disclosed.

Biologically pure culture of Streptomyces sandaensis No. 6897

The invention relates to a new compound, designated FR-68504. The compound has antitimor activities and is effective in the treatment of various tumors in both human beings and animals. There is also provided a process for preparing FR-68504 compound which comprises culturing a FR-68504 producing strain belonging to the genus Amauroascus in a nutrient medium. Pharmaceutical composition comprising FR-68504 as an active ingredient is also described.

Compound FR-68504, production thereof and use thereof

New tetracyclo compounds of the formula: ##STR1## in which R.sup.1 is formyl, protected formyl, hydroxymethyl, protected hydroxymethyl, arylaminomethyl, carboxy, protected carboxy or substituted iminomethyl,

Tetracyclo compounds and a pharmaceutical composition containing the same

The invention relates to a new compound, FR-900447, and pharmaceutically acceptable salts thereof having antimicrobial and antitumor activity, to a pharmaceutically composition thereof, and to a process for production thereof by culturing Streptomyces rubropurpureus FERM BP-584 in nutrient medium under aerobic condition.

Compound, FR-900447, production and use thereof

Novel compounds designated as WS 6049-A and WS 6049-B are disclosed, as well as compositions containing the compounds thereof, a method of treating microbial infections, a method of prolonging the survival time of the patient with lymphocytic leukemia by administering the compounds thereof, and a process for making the WS 6049 substances, are disclosed. As indicated above, the novel compounds have antimicrobial and antileukemic activities which make them useful against a variety of pathogenic microorganisms and leukemic tumors.

Growing community of inventors

Toyonaka, Japan

Hiroshi Terano