Canon Kabushiki Kaisha

Ajinomoto Co., Ltd.

Nara Institute of Science and Technology

Other

Mitsubishi Pencil Company, Limited

Mitsubishi Pencil Kabushiki Kaisha

Seiren Kabushiki Kaisha

Canon Denshi Kabushiki Kaisha

Tohoku Steel Co., Ltd.

Fuji Xerox Co., Ltd.

Amano Pharmaceutical Co., Ltd.

National University Corporation Nara Institute of Science and Technology

Hiroshi Takagi

Kenji Suzuki

Shigeru Nakamori

Morimi Hashimoto

Akira Shinmi

Takayuki Yagi

Noriaki Ohguri

Kazuo Kuroda

Nobuyuki Saito

Takeshi Sawada

Kentaro Takemae

Masahiro Fushimi

Fumio Kishi

Hideyuki Yamada

Yoshimasa Okamura

Masaru Wada

Kazuhisa Tsujimoto

Iwao Ohtsu

Masakazu Takahashi

Susumu Kozuki

Masahiro Haruta

Hideaki Mitsutake

Kunitaka Ozawa

Yukuo Nishimura

Eigo Kawakami

Nobutoshi Mizusawa

Takao Kusaka

Kiyoshi Miwa

Atsushi Shiozaki

Yuji Kasanuki

Konosuke Sano

Takashi Noma

Gen Nonaka

Toshiaki Asano

Masaaki Ishida

Hirokazu Goto

Mitsunobu Nakazawa

Shuzo Abiko

Takeshi Nakatani

Toshiaki Serikawa

Yoichi Ohsato

Kunihiko Tanaka

Mitsutoshi Hasegawa

Yutaka Arai

Yoichi Osato

Mikhail Markovich Gusyatiner

Hiroshi Matsui

Masao Sugata

Kazuaki Ohmi

Hisanori Tsuda

Ihachiro Gofuku

Ryo Fujimoto

Hitoshi Suzuki

Kazuya Shigeoka

Tsuyoshi Murakami

Katsumi Arisaka

Tatsuki Kashiwagi

Hiromitsu Takase

Koichi Ito

Takao Sasakura

Kou Yoneda

Takahiko Ishiwatari

Ko Yoneda

Kohki Ishikawa

Toshihide Yoshimura

Ei-ichiro Suzuki

Tomoko Murakami

Takashi Isoda

Mikhail Kharisovich Ziyatdinov

Takaaki Sato

Tokio Matsumoto

Hisao Fumoto

Hideshi Hiruta

Rieko Kanome

Kinya Washizu

Yuko Kai

Yu Sasano

Hirotada Mori

Jun Shima

Yutaka Haitani

Shino Arafuka

Keiichi Ando

Satoshi Koikeda

Ryusuke Homma

Noriaki Tsunoda

Ekaterina Igorevna Redkina

Ai Tamakoshi

Sayo Takahashi

Natthawut Wiriyathanawudhiwong

L-cysteine can be produced inexpensively and efficiently by using a bacterium belonging to the family Enterobacteriaceae modified to reduce activity of O-acetylserine sulfhydrylase B thereof, the bacterium being modified so that the C terminal region of its thiosulfate-binding protein is deleted, and the bacterium having an increased ability to produce L-cysteine in the presence of a sulfate.

Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability

The present invention provides yeast having increased resistance to freezing stress in which POG1 gene is inactivated, a method for producing such yeast, and a method for using such yeast in food production.

Yeast having resistance to freezing stress

An information processing apparatus includes a sample extracting unit, a trail information memory, a trail acquisition instructing unit, a trail accepting unit, and a trail determining unit. The sample extracting unit extracts samples from a population. The trail information memory stores information about trails. The trail acquisition instructing unit provides an instruction to acquire a trail for a sample extracted by the sample extracting unit. The trail accepting unit accepts trails. The trail determining unit determines, every time the trail accepting unit accepts a trail, whether the accepted trail is valid or invalid in accordance with the information stored in the trail information memory. If the trail determining unit determines that the accepted trail is invalid, the trail acquisition instructing unit provides again an instruction to acquire a trail.

Information processing apparatus, trail collection system, information processing method, and non-transitory computer readable medium

The present invention provides a bacterium belonging to the family Enterobacteriaceae, which is able to produce L-cysteine and has been modified to increase the activity of the protein encoded by the dsbA gene. This bacterium is cultured in a medium, and L-cysteine, L-cystine, a derivative or precursor thereof or a mixture thereof can be collected from the medium.

L-cysteine-producing bacterium and a method for producing L-cysteine

L-Cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which has L-cysteine-producing ability and has been modified so that the activity of a protein encoded by a tolC gene, for example, a protein defined in the following (a) or (b), is increased in a medium, and by collecting L-cysteine, L-cystine, a derivative or precursor thereof, or a mixture thereof from the medium:

L-cysteine is produced by culturing anbacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or eliminated. The bacterium is cultured in a medium to produce and cause accumulation of L-cysteine in the medium, and collecting L-cysteine from the medium.

L-cysteine producing microorganism and a method for producing L-cysteine

The present invention provides a mutant-type acetyltransferase Mpr1: which comprises an amino acid sequence of a yeast wild-type Mpr1 represented by SEQ ID NO:1, wherein at least one amino acid at positions 63 to 65 and 117 of the amino acid sequence is substituted and said mutant-type acetyltransferase Mpr1 exhibits a higher antioxidant capacity than the wild-type Mpr1. The mutant-type acetyltransferase Mpr1 of the present invention exhibits a higher resistance to oxidative stress compared to the wild-type Mpr1. The present invention further provides a gene encoding the mutant-type Mpr1, a vector comprising the gene and a yeast transformed with the gene.

Mutant-type acetyltransferase Mpr1

A peptide according to the present invention is selected from the group consisting of: (a) a peptide having the amino acid sequence represented by SEQ ID NO: 1; (b) a peptide having a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having cell death-preventing activity and/or cell growth-promoting activity; and (c) a peptide which has an amino acid sequence having at least 80% homology with the peptide consisting of the amino acid sequence described in (a) above and has cell death-preventing activity and/or cell growth-promoting activity. The peptide has cell death-preventing activity and/or cell growth-promoting activity, is highly safe, and can be produced without difficulty. The peptide is useful as a culture supplement or as an effective component for a cell culture medium.

Physiologically active peptides

An objective of the present invention is to provide a new protein derived from the silkworm middle silk gland and a DNA encoding said protein. The present invention relates to a protein of the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 1; (b) a protein comprising a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having protease activity.

Protein and DNA encoding the same

O-acetylserine, L-cysteine and sulphurous compounds derived therefrom may be produced using a bacterium belonging to the genuswhich harbors a mutant feedback-resistant serine acetyltransferases in which the amino acid sequence corresponding to positions from 89 to 96 in a wild-type serine acetyltransferase is replaced with any one of the amino acid sequences shown in SEQ ID NOS: 4 to 9, and feedback inhibition by L-cysteine in the bacterium is desensitized.

Mutant serine acetyltransferase

L-cysteine is produced by culturing a coryneform bacterium in which intracellular serine acetyltransferase activity is increased by transformation with a gene coding for serine acetyltransferase, such modification of an expression control sequence of a gene coding for serine acetyltransferase that expression of the gene in a cell should be enhanced and for forth, preferably in which L-cysteine decomposition system is further suppressed, in a medium to produce and accumulate L-cysteine in culture and collecting the L-cysteine from the culture.

L-cysteine producing bacterium and method for producing L-cysteine

The mechanism includes: an urging means for urging an inner needle () to the side opposite to an outer needle () with respect to the axial direction of a holder sleeve () for holding the inner needle (); an actuator () which is positioned between the urging means () and inner needle (), moves together with the inner needle () and has a puncture position retainer for keeping the inner needle () and outer needle () ready for puncture and an inner needle retraction actuating portion for allowing for the retraction actuation of the inner needle (); and a slit () for assuring the path of movement of the actuator (). The puncture position retainer has a puncture position engagement portion whereby the actuator () is engaged with the holder sleeve () at a position on the outer needle side (). The inner needle retraction actuating portion includes: an actuating portion () for releasing the actuator () from the engaged state of the puncture position engagement portion into the urged state by the urging means () and an actuator housing for enclosing the actuator after retraction of the inner needle.

Safety indwelling needle

L-Cysteine is produced by culturing a bacterium belonging to the genushaving an L-cysteine producing ability and modified so that cystathionine-&#x3b2;-lyase activity or cystathionine-&#x3b2;-lyase activity and tryptophanase activity should be reduced or eliminated in a medium to produce and accumulate L-cysteine in the medium and collecting the L-cysteine from the medium.

An objective of the present invention is to provide a means to prevent freeze-induced decrease in protein activity. The present invention relates to a method for preventing freeze-induced decrease in protein activity comprising adding a polypeptide comprising the following amino acid sequence (I) to a protein to be frozen. Further, the present invention relates to use of a polypeptide comprising the following amino acid sequence (I) to produce an agent for preventing freeze-induced decrease in protein activity: 

Method of preventing decrease in the activity of protein due to freezing and use of polypeptide in the production of protein activity decrease preventing agent

A four-wheel drive vehicle includes a coupling, which varies the distribution ratio of torque to the front wheels and the rear wheels. The distribution ratio of torque to the front wheels and the rear wheels is determined by the engaging force of the coupling. An ECU sets first to third determination threshold values for the opening degree of a throttle valve of an engine in accordance with the detected vehicle speed. The ECU determines whether the vehicle is in a steady driving state by comparing the detected throttle opening degree with the set first to third determination threshold values and controls the engaging force of the coupling in accordance with the determination result. Thus, the steady driving state of the vehicle is correctly determined.

Power distribution control apparatus for four-wheel drive vehicle

Growing community of inventors

Yokohama, Japan

Hiroshi Takagi