Bonac Corporation

Hiroshi Suzuki

Tadaaki Ohgi

Tomohiro Hamasaki

Akihiro Itoh

Hisao Shirohzu

Hirotake Hayashi

Eriko Aoki

Takayuki Mizutani

The invention provides a microRNA inhibitor that has two or more sequences complementary to the sequence of microRNA to be the target of inhibition, which two or more complementary sequences are linked via one or more linker residues.

Micro-RNA inhibitor

The invention provides a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at low cost and can produce a nucleic acid in high yield and with high purity. The glycoside compound has the formula wherein B, R1, R2, and R3 are as described herein.

Glycoside compound, method for producing thioether, ether, method for producing ether, method for producing glycoside compound, method for producing nucleic acid

The invention provides a single-stranded nucleic acid molecule containing an expression inhibitory sequence that inhibits expression of a target gene, region (X), linker region (Lx), and region (Xc), wherein the linker region (Lx) is linked between the region (Xc) and the region (Xc), the region (Xc) is complementary to the region (X), at least one of the region (X) and the region (Xc) contains the expression inhibitory sequence, and the linker region (Lx) contains an atomic group derived from an amino acid. The single-stranded nucleic acid molecule can inhibit expression of the target gene.

Single-stranded nucleic acid molecule having amino acid backbone

The invention provides a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at low cost and can produce a nucleic acid in high yield and with high purity. The glycoside compound has the formula wherein B, R, and Rare as described herein, Ris &#x2014;OCH(OCH)&#x2014;O-L-[D], in which Lis an ethylene group, wherein hydrogen atoms besides a hydrogen atom bonded to the &#x3b1;-position relative to [D] are optionally substituted by a straight chain or branched alkyl group, n is a positive integer, and [D] is an electron-withdrawing group.

Micro-RMA inhibitor

Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton

Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5' side to the 3&#x2032; side: a 5&#x2032; side region (Xc); an inner region (Z); and a 3&#x2032; side region (Yc). The inner region (Z) is composed of an inner 5&#x2032; side region (X) and an inner 3&#x2032; side region (Y) that are linked to each other. The 5&#x2032; side region (Xc) is complementary to the inner 5&#x2032; side region (X). The 3&#x2032; side region (Yc) is complementary to the inner 3&#x2032; side region (Y). At least one of the inner region (Z), the 5&#x2032; side region (Xc), and the 3&#x2032; side region (Yc) includes the expression inhibitory sequence.

Growing community of inventors

Itami, Japan

Hiroshi Suzuki