Yamanouchi Pharmaceutical Company Ltd.

Other

Hiroshi Sugiura

Tadayoshi Ohmura

Hiroitsu Kawata

Masayoshi Aruga

Takashi Sonobe

Muneo Fukui

Atsushi Kajiyama

Satoru Yoneya

Toshiharu Hosono

Tomoh Itoh

Akira Ito

Masuo Murakami

Shigeru Yamazaki

Hiroitsu Kawada

The present invention is to provide a stabilized pharmaceutical composition for oral use containing 1-ethyl methylester 4-&lsqb;&lsqb;3-&lsqb;p-(carboxyamidino)phenyl&rsqb;-2-oxo-5-oxazolidinyl&rsqb;methyl&rsqb;-1-piperazineacetate or a pharmaceutically acceptable salt thereof having an antagonistic action to GPIIb/IIIa receptor and an oily base. The present invention is to further provide a method for the manufacture of a stabilized pharmaceutical composition for oral use by compounding 1-ethyl methylester 4-&lsqb;&lsqb;3-&lsqb;p-(carboxyamidino)phenyl&rsqb;-2-oxo-5-oxazolidinyl&rsqb;methyl&rsqb;-1-piperazineacetate or a pharmaceutically acceptable salt thereof with an oily base. The present invention is to furthermore provide a method for the stabilization of a pharmaceutical composition by compounding 1-ethyl methylester 4-&lsqb;&lsqb;3-&lsqb;p-(carboxyamidino)phenyl&rsqb;-2-oxo-5-oxazolidinyl&rsqb;-methyl&rsqb;-1-piperazineacetate or a pharmaceutically acceptable salt thereof with an oily base.

Pharmaceutical composition for oral use

A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

Drug release controlling coating material for long acting formulations

A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ration, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

Drug-release controlling coating material for long acting formulations

Long acting formulations of amosulalol hydrochloride are provided, wherein the frequency of administering the hypotensive agent is minimized and wherein such formulations are prepared by compounding amosulalol hydrochloride with an enterosoluble material and optionally the inclusion of an organic acid.

Amosulalol hydrochloride long acting formulations

Amosulalol hydrochloride long acting formulation

A single phase solid composition wherein one part of a non-aqueous liquid and 0.5-6 parts of calcium lactate hydrate are mixed and heated. The product according to this invention is very stable and can be formed into various kinds of moldings by a simple operation so that it may be applied to many uses.

Solid composition

Growing community of inventors

Shizuoka, Japan

Hiroshi Sugiura