Taiho Pharmaceutical Company Limited

Hiroshi Sootome

Morihiro Mitsuya

Tetsuya Sugimoto

Hidekazu Takahashi

Norio Masuko

Akihiro Miura

Satoru Ito

Takeshi Sagara

Hiroshi Hirai

Sachie Otsuki

Junya Iwasaki

It is intended to provide a novel method for treating a cancer using an FGFR inhibitor that exhibits a remarkably excellent antitumor effect and has fewer side effects. The present invention provides a combination preparation for the treatment of a malignant tumor comprising a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof, and one or more additional compound(s) having an antitumor effect or pharmaceutically acceptable salt(s) thereof, and a pharmaceutical composition comprising both the active ingredients. The present invention also provides an antitumor effect enhancer, an antitumor agent, a kit for malignant tumor treatment, etc. comprising a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.

Preparation and composition for treatment of malignant tumors

The problem to be solved by the present invention is to provide an anticancer agent for treating tumors resistant to other antitumor agents that inhibit FGFR, and a method for treating such tumors. The present invention provides an antitumor agent for administration to a tumor patient resistant to an FGFR inhibitor, the antitumor agent comprising a 3,5-disubstituted benzene alkynyl compound represented by Formula (I) below or a salt thereof. The present invention also provides a therapeutic method using the anticancer agent. 

Therapeutic agent for FGFR inhibitor-resistant cancer

A novel compound which has an excellent aurora A-selective inhibitory action and is useful as an orally administrable anticancer agent is provided. Also, a novel agent for potentiation of anti-tumor effect of microtubule agonists, which include a taxane anticancer agent, and a combination therapy are provided. A piperidine compound represented by a general formula (I) or a salt thereof: 

Piperidine compound or salt thereof

The present invention provides a compound represented by Formula (I) (wherein R, X, X, Y, and Z are as defined in the specification), or a salt thereof.

3,5-disubstituted alkynylbenzene compound and salt thereof

A method for treating a tumor by combining a piperidine compound of formula (I) or salt thereof and a microtubule-targeting drug, in which the microtubule-targeting drug is administered once per 7 days or more one cycle, and the piperidine compound is administered once or more per day for 4 days or more: 

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Tsukuba, Japan

Hiroshi Sootome