Eisai Company, Limited

Other

Chondrex Inc.

Muromachi Chemical Co., Ltd.

Combi Corporation

Asama Chemical Co., Ltd.

Muromachi Kagaku Kogyo Kaisha, Ltd.

Hiroshi Shionoya

Nozomu Koyanagi

Haruyoshi Arai

Hitoshi Takeuchi

Sadaichi Iwashita

Shizumasa Kijima

Kuniaki Terato

Norio Minami

Kiyomi Yamatsu

Kimio Hamamura

Mizuo Yajima

Satoshi Katayama

Yuzuru Homma

Gunki Funatsu

Futoshi Okada

Masuo Hosokawa

Yoshiki Sugihara

Chiyoji Abe

It is believed that the abnormal absorption of endotoxin present in the gastrointestinal tract relates to the pathogenesis of autoimmune diseases such as rheumatoid arthritis. In an animal model for rheumatoid arthritis, it is observed that arthritis is improved by removing endotoxin. The present invention provides an endotoxin-adsorbent, which is capable of removing endotoxin in the gastrointestinal tract and can be administered to humans safely. By using a non-digestible and non-absorbable, and therefore, safe endotoxin-adsorbent, which has a high endotoxin-binding capacity for removing large amounts of endotoxin present in the gastrointestinal tract, it is possible to prevent and treat autoimmune diseases such as rheumatoid arthritis.

Endotoxin adsorbent for the prevention and treatment of autoimmune diseases

Endotoxin-adsorbent for the prevention and treatment of autoimmune diseases

The invention prevents or treats a tumor, inhibiting tumor growth and malignant progression by providing an antitumor agent containing a treated SOD as the active ingredient, especially a melon SOD coated with gliadin. The invention also applies to a method of preventing or treating the tumor.

Anti-tumor agent

An immunomodulator having suppressive activity on IgE antibody production is provided and contains bacterial cells, or their decomposition materials. It can be taken as a food. Bacterial cells such as Corynebacterium, Brevibacterium, Microbacterium, or bacterial cells of mutant strains of these bacteria, or decomposition products of these bacteria are used.

Immunomodulator, immunomodulator food

Compound bearing two, 2,6-diiodophenol-4-YL groups and diagnostic drug

An immunopotentiator comprising the B chain of ricin as an active ingredient. The immunopotentiator serves to increase immune response to fungi, viruses and other microorganisms and is therefore effective for prevention or treatment of infectious diseases by such microorganisms.

Immunopotentiator comprising the B chain of ricin as an active ingredient

An immunopotentiator comprising ricin as an active ingredient. Ricin is a glucoprotein having a molecular weight of about 65,000 and can be used in the form of an aqueous solution. It is useful for prevention and treatment of bacterial and viral infections and cancer.

Immunopotentiator containing recin

An immunopotentiator comprising abrin as an active ingredient. Abrin is a glucoprotein having a molecular weight of about 65,000 and can be used in the form of an aqueous solution. It is useful for prevention and treatment of bacterial and viral infections.

Immunopotentiator containing abrin

Novel pyranochromone derivatives having the general formula: ##STR1## wherein R.sub.1 represents hydrogen atom, an alkali metal or an alkyl group containing 1-4 carbon atoms; R.sub.2, R.sub.3 and R.sub.4 represent hydrogen atom or an alkyl group containing 1-4 carbon atoms respectively, provided that both R.sub.3 and R.sub.4 are not hydrogen atom at the same time; R.sub.5 and R.sub.6 represent an alkyl group containing 1-4 carbon atoms respectively; and R.sub.7 represents hydrogen atom, hydroxyl group, an alkyl group containing 1-4 carbon atoms or an alkoxyl group containing 1-4 carbon atoms. The novel medicaments comprising predominantly the above derivative are effective for the treatment of allergic diseases.

Pyranochromone derivatives and therapeutic composition comprising same

Novel 5-fluorouracil derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrogen atom or methyl group, and R.sub.4 represents a straight or branched alkyl or alkenyl group, which has low toxicity and improved antitumor activity, and novel antitumor preparations containing the said 5-fluorouracil derivative.

5-Fluorouracil derivatives and antitumor preparations containing the same

The invention involves vaccine preparations comprising cell wall protein component of Pseudomonas aeruginosa as active ingredient and a pharmaceutically acceptable carrier. The preparations are suitable for parenteral administration for prophylactic treatment of disease caused by infection of Pseudomonas aeruginosa. The cell wall protein component is characterized by the fact that the same exhibits low toxicity and without type-specificity to the variety of antigens of Pseudomonas aeruginosa.

Method for prevention of pseudomonas aeruginosa infections

Growing community of inventors

Saitama, Japan

Hiroshi Shionoya