The Green Cross Corporation

Hoechst Japan Limited

Hiroshi Shinyama

Masahiro Watanabe

Takeshi Uchida

Toru Kawamura

Minori Okita

Norifumi Nakamura

Koichi Yamanouchi

Toshiaki Akira

Kazutaka Hayashi

Hideaki Kido

Yoshiji Kubo

Masahide Nakajima

Feng Wang

Katsumi Yamanaga

Yuji Narita

A method for increasing the placental blood flow, which comprises administering a human-originated antithrombin-III. The human-originated antithrombin-III increases the placental blood flow in mammals and particularly improves intrauterine growth retardation caused by a decreased blood flow. The method is highly safe to the mother and fetus, since it uses human-originated AT-III as an active ingredient, thereby enabling effective and safe treatment of intrauterine growth retardation (IUGR) and the like.

Method for increasing placental blood flow

A circulatory disorder improving agent comprising, as an active ingredient, a dihydropyridine derivative of the formula (I) ##STR1## or an acid addition salt thereof. Said circulatory disorder improving agent is particularly useful as an organ circulation disorder improving agent or peripheral circulation improving agent.

Circulatory disorder improving agent

Pharmaceutical use of dihydropyridine derivative

Growing community of inventors

Hirakata, Japan

Hiroshi Shinyama