Hamamatsu-photonics K.k.

National Institute of Health Sciences

Hiroshi Satozono

Kouichiro Akiyama

Akinori Oda

Takashi Inoue

Hironori Takahashi

Yoichi Kawada

Koyo Watanabe

Atsushi Nakanishi

Kyohei Shigematsu

Yohei Takata

Hisanari Takahashi

Kazuki Horita

Tomomi Shinke

Kazuue Fujita

Masakazu Katsumata

Ayano Takeuchi

Kimiko Kazumura

Kazuhiro Takahashi

Ryosuke Mochizuki

Tomoaki Sakamoto

Tetsuya Uchida

Tomoyuki Hakamata

A hygroscopicity evaluation method includes: a first step of preparing a first sample and a second sample; a second step of acquiring a first detection result for the first sample and a second detection result for the second sample by making a terahertz wave incident on each of the first and second samples; and a third step of evaluating the hygroscopicity of a measurement target object based on a first frequency characteristic calculated from the first detection result and a second frequency characteristic calculated from the second detection result. In the third step, the magnitude of the hygroscopicity of the measurement target object is evaluated based on the difference between the magnitude of a first peak of the first frequency characteristic in a reference frequency range and the magnitude of a second peak of the second frequency characteristic in the reference frequency range.

Hygroscopicity evaluation method and water content evaluation method

A time response measurement apparatus includes a pulse formation unit, an attenuation unit, a waveform measurement unit, and an analysis unit. The pulse formation unit generates first pulsed light including a wavelength of pump light, second pulsed light including a wavelength of probe light, and third pulsed light including the wavelength of the pump light and the wavelength of the probe light, on a common optical axis. The attenuation unit transmits the first pulsed light, the second pulsed light, and the third pulsed light output from a sample arranged on the optical axis after being incident on the sample. An attenuation rate for the pump light is larger than an attenuation rate for the probe light. The analysis unit obtains a time response of the sample based on temporal waveforms of the first pulsed light, the second pulsed light, and the third pulsed light having passed through the attenuation unit.

Time response measurement apparatus and time response measurement method

An optical property measurement apparatus includes a pulse formation unit, a waveform measurement unit, and an optical system. The pulse formation unit is capable of changing a temporal waveform of pulsed light in accordance with a type of optical property to be measured. The waveform measurement unit measures a temporal waveform of the pulsed light output from a measurement object after being incident on the measurement object. The optical system has an attenuation unit with an attenuation rate with respect to one wavelength component constituting the pulsed light larger than an attenuation rate with respect to another wavelength component constituting the pulsed light. The optical system is capable of switching between a first state in which the attenuation unit is arranged on an optical path of the pulsed light output from the measurement object and a second state in which the attenuation unit is not arranged on the optical path.

Optical property measurement apparatus and optical property measurement method

An optical element includes a laminate including a first refractive index layer and a second refractive index layer having different refractive index for terahertz waves, wherein the laminate includes a pair layer group in which a plurality of pair layers including the first refractive index layer and the second refractive index layer are laminated, wherein the thickness of the first refractive index layer and the thickness of the second refractive index layer are each smaller than a wavelength of the terahertz waves, and wherein each of the pair layers has a predetermined effective refractive index for the terahertz waves depending on a thickness ratio between the first refractive index layer and the second refractive index layer.

Optical element

Provided is a method of quantifying a target substance present in a solvent comprises acquiring a first fluorescence decay curve and a second fluorescence decay curve to acquire some factors from the curves.

Method for removing background of fluorescence lifetime measurement and method for quantifying target substance

A terahertz wave attenuated total reflection spectroscopic method, includes: a first step of disposing a measurement target of which a volume is changed during a measurement period on a reflection surface; and a second step of acquiring data including a plurality of detection results respectively corresponding to a plurality of times separated from each other during the measurement period by allowing a terahertz wave to be incident on the reflection surface from a side opposite to the measurement target and by detecting the terahertz wave reflected on the reflection surface, during the measurement period. In the second step, a state in which a substantially constant pressure is applied to the measurement target disposed on the reflection surface is maintained during the measurement period.

Terahertz wave attenuated total reflection spectroscopic method, terahertz wave attenuated total reflection spectroscopic device, and pressure application device

The present invention relates to a method for detecting an amyloid &#x3b2; oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1&#x3c;t2&#x2264;t3&#x3c;t4), and determination is made to confirm the presence or absence of an amyloid &#x3b2; oligomer in the test sample on the basis of the two normalized spectra, and shifting of the normalized spectrum of time period t3 to t4 towards the low wavelength side in comparison to the normalized spectrum of time period t1 to t2 indicates the presence of an amyloid &#x3b2; oligomer in the test sample.

Amyloid &#x3b2; oligomer detection method, amyloid &#x3b2; oligomer detection device, and amyloid &#x3b2; oligomer detection program

The present invention relates to a method for purifying pure thioflavin T having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent and a step of carrying out liquid-liquid extraction of the thioflavin T solution with a non-polar solvent.

Liquid-liquid extraction methods for purifying and producing pure thioflavin T by monitoring light emission intensity of thioflavin T

Provided is a polymer resin orientation evaluation method including: setting an axis intersecting a front surface of an object to be inspected as an inspection axis, and acquiring an optical characteristic value of the object to be inspected with respect to a plurality of polarization directions of a terahertz wave around the inspection axis; and evaluating orientation of a polymer resin that constitutes the object to be inspected on the basis of a variation amount of the optical characteristic value with respect to change of the polarization direction.

Polymer resin orientation evaluation method

A fermentation state monitoring apparatus includes: a terahertz wave generation element that outputs inspection light using a terahertz wave to a fermented food under fermentation in a sealed product container; a terahertz wave detection element that detects return light of the inspection light reflected by the fermented food in the product container; and a determination unit that determines a fermentation progress of the fermented food based on an index value including a reflectance of the return light with respect to the inspection light or an absorption coefficient of the return light with respect to the inspection light.

Fermentation state monitoring apparatus and fermentation state monitoring method

The present invention relates to a method for purifying pure thioflavin T in having a step of preparing a thioflavin T solution in which crude thioflavin T is dissolved in a polar solvent, a step of bringing the thioflavin T solution into contact with a non-polar polymeric porous body, and a step of separating the thioflavin T solution after the contact from the non-polar polymeric porous body.

Method for purifying pure thioflavin T, method for producing pure thioflavin T, composition including thioflavin T, and amyloid detection method

An optical measurement device includes a light source configured to output a terahertz wave and coaxial light having a wavelength different from the wavelength of the terahertz wave, coaxially with the terahertz wave; an intensity modulation unit configured to perform intensity modulation of at least the terahertz wave of the terahertz wave and the coaxial light in a predetermined modulation frequency; and a light detection unit configured to synchronously detects each of the terahertz wave and the coaxial light which have acted on a measurement subject via the intensity modulation unit based on the modulation frequency.

Optical measurement device and optical measurement method

Circular dichroism can be accurately measured even when a phase modulation element with a distortion component is used. A circular dichroism measuring method using a circular dichroism measuring deviceincludes a step of measuring Ip(t) (S: phase amount change acquisition step), a step of measuring Is(t) (S: sample data acquisition step), a step of converting Ip(t) to &#x3b4;(t) (S: phase amount change acquisition step), a step of converting Is(t) to Is(&#x3b4;) (S: analysis step/Is(&#x3b4;) calculation step), and a step of performing curve fitting to calculate matrix elements S, S, and S(S: analysis step/matrix element calculation step).

Circular dichroism measuring method and circular dichroism measuring device

Circular dichroism can be accurately measured even when a phase modulation element with a distortion component is used. A circular dichroism measuring method using a circular dichroism measuring deviceincludes a step of measuring Ip(t) (S: phase amount change acquisition step), a step of measuring Is(t) (S: sample data acquisition step), a step of converting Ip(t) to &#x3b4;(t) (S: phase amount change acquisition step), a step of converting Is(t) to Is(&#x3b4;) (S: analysis step/Is(&#x3b4;) calculation step), and a step of performing curve fitting to calculate matrix elements S00, S02, and S03 (S: analysis step/matrix element calculation step).

An object of the present invention is to appropriately and easily evaluate a photosynthetic function of a photosynthetic sample contained in an evaluation sample. An evaluation method for photosynthetic sample according to the present invention is for evaluating a state of a photosynthetic sample with a photosynthetic function based on temporal data of a luminescence amount of delayed luminescence emitted from the photosynthetic sample. First, characteristic values that indicate characteristics are determined for a plurality of time periods in the temporal data. An evaluation value is then computed by weighting the characteristic values. The state of the photosynthetic sample is then evaluated based on the evaluation value.

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Hamamatsu, Japan

Hiroshi Satozono