Mitsubishi Tanabe Pharma Corporation

Mitsubishi Denki Kabushiki Kaisha

Denki Kagaku Kogyo Kabushiki Kaisha

Mitsubishi Pharma Corporation

Hiroshi Sakashita

Fumihiko Akahoshi

Tomohiro Yoshida

Yoshiharu Hayashi

Hiroshi Kitajima

Shoji Yoshikawa

Katsuhiko Yamada

Naoko Ueda

Shinji Kirihara

Satoru Uemori

Reiko Tsutsumiuchi

Hiroo Yonechi

Takashi Kawasaki

Shinji Saito

Takehiko Sawai

Masahiro Takeuchi

Kunitomo Adachi

Maiko Hamada

Masatoshi Kiuchi

Yoshihito Tanaka

Shuzo Takeda

Kaoru Tashiro

Atsushi Numata

Saori Tahara

Hisashi Kawasumi

Takuya Yoshimura

The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, which has a superior peripheral blood lymphocyte decreasing action, and is useful for the treatment or prophylaxis of autoimmune diseases; prophylaxis or suppression of resistance or acute rejection or chronic rejection of transplantation of organ or tissue; treatment or prophylaxis of graft-versus-host (GvH) disease due to bone marrow transplantation; or treatment or prophylaxis of allergic diseases.

Amine compound and use thereof for medical purposes

The present invention provides 3-{(2S,4S)-4-[4-(3-methyl -1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2 -ylcarbonyl}thiazolidine (compound I) useful as a dipeptidyl peptidase-IV inhibitor, which has superior properties of stability and hygroscopicity, and reproducible crystal structure, and a production method thereof.

Salt of proline derivative, solvate thereof, and production method thereof

Provided is a positive electrode material for a safe, high capacity, long lifetime lithium ion secondary battery capable of large current charging and discharging. The positive electrode material contains between 5% by mass or more and 30% by mass or less of a carbon black composite formed by joining together fibrous carbon and carbon black wherein ash is 1.0% or less by mass in accordance with JIS K 1469 and the remainder includes olivine-type lithium iron phosphate, and volatile oxygen-containing functional groups which constitutes 1.0% or less by mass of the positive electrode material. The fibrous carbon is preferably a nanotube having a fiber diameter of 5 nm or more and 50 nm or less and a specific surface area between 50 m/g or more and 400 m/g or less.

Positive-electrode material for a lithium ion secondary battery and manufacturing method of the same

The invention provides a sulfonyl malonamide derivative, or a pharmacologically acceptable salt thereof or a solvate thereof, that has therapeutic and/or preventive effects(s) on various diseases due to its agonist action at ATreceptor, and is useful as a pharmaceutical agent for the treatment and/or prevention of diseases involving the renin-angiotensin-aldosterone system (RAAS).

Malonic acid sulfonamide derivative and pharmaceutical use thereof

The present invention provides a granulated acetylene black which can be easily and well dispersed when it is incorporated in at least one of a resin and a rubber, the process for producing it, and its composition. A granulated acetylene black has an average aspect ratio of at most 1.1, an average maximum particle size of from 0.2 mm to 1 mm and an average particle size of from 0.2 to 0.6 mm. The granulated acetylene black is produced, after stirring and granulating a mixture containing from 35 to 50 mass % of an acetylene black original powder having an iodine adsorption amount of from 80 to 100 mg/g and a DBP absorption amount of from 140 to 220 ml/100 g and from 50 to 65 mass % of water, and subjecting to selection treatment, classification treatment or both treatments.

Granulated acetylene black, process for producing it and its composition

The present invention provides 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine (compound I) useful as a dipeptidyl peptidase-IV inhibitor, which has superior properties of stability and hygroscopicity, and reproducible crystal structure, and a production method thereof.

A thiazolidine derivative represented by the formula (I) wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.

Thiazolidine derivatives and medicinal use thereof

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the &#x3b3;-position of proline represented by the formula (I)wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

Proline derivatives and the use thereof as drugs

The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the &#x3b3;-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

Proline derivatives and use thereof as drugs

An attitude determination system for an artificial satellite capable of performing star identification without need for the aid of ground station includes an image processing module (,) for processing star images observed at predetermined time points by a star sensor (,) mounted on the artificial satellite (,) for arithmetically determining direction vectors of the observed stars, a rotation estimating module (,) for estimating a rotational motion of the artificial satellite (,) between an attitude of the artificial satellite at a predetermined time point and an attitude of the artificial satellite at another time point, an elongation estimating module (,) for estimating elongations between the direction vectors of plural stars the images of which are picked up at a same time point by the star sensor and estimating the elongations between the direction vectors of plural stars the images of which are picked up at different time points by the star sensor on the basis of the estimated rotational motion, a star identifying module (,) for establishing correspondences between a plurality of the stars for which relation of the elongation has been determined and stars on a star catalog for identifying the stars, and an attitude angle estimating module (,) for estimating an attitude angle of the artificial satellite on the basis of result of identification of the stars.

Attitude determination system for artificial satellite

An attitude determination system for an artificial satellite capable of performing star identification without need for the aid of ground station includes an image processing module (17) for processing star images observed at predetermined time points by a star sensor (16) mounted on the artificial satellite (1) for arithmetically determining direction vectors of the observed stars, a rotation estimating module (18) for estimating a rotational motion of the artificial satellite (1) between an attitude of the artificial satellite at a predetermined time point and an attitude of the artificial satellite at another time point, an elongation estimating module (19) for estimating elongations between the direction vectors of plural stars the images of which are picked up at a same time point by the star sensor and estimating the elongations between the direction vectors of plural stars the images of which are picked up at different time points by the star sensor on the basis of the estimated rotational motion, a star identifying module (20) for establishing correspondences between a plurality of the stars for which relation of the elongation has been determined and stars on a star catalog for identifying the stars, and an attitude angle estimating module (21) for estimating an attitude angle of the artificial satellite on the basis of result of identification of the stars.

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Tokyo, Japan

Hiroshi Sakashita