Nikon Corporation

Chugai Seiyaku Kabushiki Kaisha

Sony Corporation

Ajinomoto Co., Ltd.

Japan Tobacco Inc.

Showa Denko K.k.

Kabushiki Kaisha Toshiba

Fujitsu Corporation

Nishimu Electronics Industries Co., Ltd.

Hiroshi Sakamoto

Hideki Matsui

Nobuyoshi Hagiuda

Norikazu Yokonuma

Ryotaro Takayanagi

Yoshikazu Iida

Toshiyuki Tsukaguchi

Kazuyuki Kazami

Takahiro Yamaguchi

Koji Takeuchi

Takashi Emura

Yoshiyuki Ono

Nobuhiro Oikawa

Nobuaki Hisamatsu

Masafumi Kikuchi

Hatsuo Kawada

Koosuke Harada

Kenji Morikami

Nobuya Ishii

Toshiya Ito

Yozo Tanaka

Noriyuki Furuichi

Tomoaki Kobayashi

Kazutomo Kinoshita

Toshihiro Arai

Yasuharu Kato

Kohsuke Asoh

WooSang Hong

MinJeong Park

Tatsushi Kodama

Tomohiro Obita

Masahiro Abe

Tetsuro Goto

Daiki Tsukahara

Masaru Muramatsu

Seiichi Yasukawa

Sueyuki Ohishi

Hideo Hibino

Tadahiko Yokota

Hiroshi Nishikawa

Takayuki Irikura

Kiyomiki Hirai

Mikio Izumi

Masato Kobayashi

Shigenobu Kushihashi

Teruji Tarumi

Hiroshi Orikabe

Toshio Onodera

Hiroyasu Koto

Masayuki Sudo

Kenji Iwai

Yoshimi Maekawa

Junji Ohashi

Akira Yunoki

Michiaki Takatsu

Masahito Shoyama

Yutaka Kondoh

Masahiko Kamiyama

Katuya Kondoh

Norikazo Yokonuma

Sumio Toyama

Takashi Kamio

The present invention relates to a drug that is for treating or preventing cancer, that is effective in the treatment of cancer, and that comprises a combination of an ALK inhibitor and a VEGF inhibitor. The present invention also relates to a method for treating or preventing cancer and a method for inhibiting tumor growth.

Combination drug

A compound represented by the following general formula (I) [the symbol in the formula are as defined in the description], a salt thereof, or the like is a RET inhibitor or RET tyrosine kinase inhibitor that can he used as an agent for the prevention or treatment of disorders including cancers and cancer metastasis having mutations in RET. 

RET inhibitor

A compound represented by the following general formula (I) [the symbol in the formula are as defined in the description], a salt thereof, or the like is a RET inhibitor or RET tyrosine kinase inhibitor that can be used as an agent for the prevention or treatment of disorders including cancers and cancer metastasis having mutations in RET. 

A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or cognitive function disorder: 

Tetracyclic compound

The present inventors examined the inhibitory activity against HCV replicon of myriocin, fumonisin B1, and ceramide trafficking inhibitor HPA-12, which are compounds derived from microorganisms such as those of the genus, and found that these compounds have the effect of inhibiting the replication of HCV replicon RNAs or inhibiting the expression of HCV proteins. The present inventors further performed serine palmitoyltransferase knockdown experiments using siRNAs, and results showed that HCV replicon activity and HCV protein expression were significantly inhibited in cells with suppressed LCB1 expression. Thus, sphingolipid biosynthesis was found to be involved in HCV infection. This showed that HCV infection can be treated or prevented by inhibiting enzyme activities involved in the process of sphingolipid biosynthesis by adding compounds or knocking down a gene.

Pharmaceutical agents for treating HCV infections

The present invention provides a method for manufacturing a conductive structure having high electrical conductivity, and a method for manufacturing a dimensionally accurate separator for a fuel cell having high electrical conductivity. In the present invention, the cavity surface temperature of a mold is kept equal to or higher than the crystal melting temperature (T) of composite material until the shaping of the composite material melted in the mold is completed, and after the completion of the shaping process, the cavity surface temperature of the mold is controlled to be equal to or higher than a temperature 20&#xb0; C. lower than the crystallization temperature (T) of the composite material but equal to or lower than a temperature 20&#xb0; C. higher than the crystallization temperature of the composite material to harden the composite material.

Electroconductive structure, manufacturing method therefor, and separator for fuel cell

The present invention are to provide an electrically conducting resin composition for a fuel cell separator which overcomes the drawbacks of prior arts, and to provide a fuel cell separator produced by molding this electrically conducting resin composition and having both of high electrical conductivity and flexural property. The present invention employs an electrically conducting resin composition for a fuel cell including a component A of polypropylene resin whose melt flow rate is 0.01 or higher and 10 or lower and a component B of electrically conducting filler as well as a fuel cell separator made of the same.

Electrically conducting resin composition for fuel cell separator and fuel cell separator

A plant protection instrumentation equipment, comprises, a sensor that detects a process signal indicating a quantity of a state of a plant, a plurality of A/D converters, each of the A/D converters converts the process signal into a digital signal and outputs a value corresponding to the digital signal, a plurality of instrumentation circuits, each of the instrumentation circuits receives the value corresponding to the process signal and performs a logical operation using the value, and a judgment circuit that judges the state of the plant based on outputs of the plurality of instrumentation circuits and outputs an operation signal based on the process signal, wherein each of the instrumentation circuits comprises a logical integrated circuit including a set value comparator that compares the value corresponding to the process signal with a predetermined set value, and outputs a signal when the value corresponding to the process signal exceeds the set value.

Plant protective instrumentation equipment

Provided are a latent curing agent that gives an epoxy resin composition with improved storage stability and low-temperature curability; and a curable epoxy resin composition prepared by mixing the said curing agent and an epoxy compound. The epoxy resin composition has improved storage stability, and cures at lower temperatures for a shorter period of time than conventional ones. The latent curing agent for epoxy resin comprises two components, (A) a radically polymerized polymer of a monomer having at least a polymerizable double bond, which has at least a tertiary amino group in the molecule, and (B) a polymer having at least a hydroxyl group in the molecule, and forms a solid solution that is solid at 25&#xb0; C.

Latent curing agent for epoxy resin, and curable epoxy resin composition

A thermosetting resin composition that is useful as an epoxy resin-based overcoating agent for flexible circuit boards or for film carriers for the TAB method, and the like, providing basic properties required of general insulation protective films, since the cured coated films are excellent in adhesiveness, electric insulation property, chemical resistance, thermal resistance, and the like, reduced in warp caused by cure shrinkage, and excellent in flexibility.

Thermosetting resin composition and flexible circuit overcoating material comprising the same

A switching power source apparatus reduces power loss and improves conversion efficiency of a switching power source part by rectifying and smoothing a commercially available alternating power source supplied to an oscillation drive circuit and a switching circuit part that constitutes a half-bridge circuit. An output of the half-bridge circuit is grounded via a resonance capacitor, a choke coil, and a primary winding of an insulated type converter transformer. This converter transformer has a secondary winding for obtaining a &plus;B voltage and high-voltage windings for obtaining a high-level output voltage. Further, fluctuation in the voltage of the high-level output voltage is supplied to the oscillation drive circuit via resistors, a control circuit, and a photo-coupler, whereby the switching circuit part is controlled. The secondary winding is connected in series to a saturable reactor, so that by controlling the inductance of this saturable reactor, the &plus;B voltage taken out from the secondary winding is controlled.

Switching power source apparatus

An automatic paper web connecting apparatus includes a pair of blocks arranged so as to be able to move relatively and be pressed against each other in the direction to cross a feed path for one paper web and a feed path for the other paper web, retaining mechanism for retaining the two paper webs on the respective opposite faces of their corresponding blocks by suction, a cutting mechanism for cutting a desired one of the paper webs, and a drive mechanism for relatively moving the blocks. The cutting mechanism includes a rotating body rockable between the two paper web feed paths on the upper-course side of the blocks, first and second knives fixed individually to the blocks, and a third knife fixed to the rotating body. The rotating body is rotated between a first rotational position in which the third knife faces the first knife and a second rotational position in which the third knife faces the second knife. The desired one paper web is cut by means of the third knife and one of the first and second knives, which is selected depending on the rotational position of the rotating body, while the blocks are moving relatively to each other.

Automatic web material connecting apparatus

A turntable is a table mounted to a shaft (4) of a spindle motor and the turntable supports a laminated disc thereon and drives the disc in rotation. The laminated disc includes a lower disc and an upper disc stacked on the lower disc, and is supported on a disc-supporting surface. When the disc is loaded on the turntable, a fitting member fits into the center hole of the laminated disc for centering the laminated disc with respect to the shaft. The fitting member fits the center hole of the lower disc when the laminated disc is supported on said disc-supporting surface. The turntable may include a tapered member which guides the laminated disc to the disc-supporting surface. The laminated disc includes lower and upper discs each having an edge which defines the center hole. The corners of the edges are cut away along a circumference of the center hole. The upper and lower discs are placed together so that the cut-away corner directly face each other.

Recording and reproducing apparatus and recording and reproducing method

Growing community of inventors

Kawasaki, Japan

Hiroshi Sakamoto