Dainippon Pharmaceutical Company, Limited

Hiroshi Okazaki

Fuminori Sato

Takashi Deguchi

Ryotaro Shiratake

Akemi Kuromiya

 Heterocyclic compounds represented by the general formula (I) and having elastase inhibiting activity; and intermediates for the synthesis thereof: (I) wherein Ris a heterocyclic group represented by the general formula (II): (II) [wherein A represents the presence or absence of a benzene ring; X is oxygen, sulfur or NH; and Y is nitrogen or CH], and the heterocyclic group may be substituted with one to three substituents which may be the same or different and are selected from the group consisting of lower alkyl, lower alkoxy, and phenyl which may be substituted with optionally halogenated lower alkyl, lower alkoxy or halogeno; and Rand Rare each hydrogen or hydroxyl, or Rand Rmay be united to form an oxo group, with the proviso that both are not hydrogen.

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Toyonaka, Japan

Hiroshi Okazaki