Toyo Kohan Co., Ltd.

Yamaguchi University

Hiroshi Okamura

Michifumi Tanga

Mitsuyoshi Ohba

Hirofumi Yamano

Masaaki Oka

Kenichi Takagi

Naoko Nakazawa

Shouichi Hazama

Kaoru Yamakawa

Teruhisa Icihara

Shyuichi Kamei

It is intended to provide a solid support capable of immobilizing nucleic acid molecules in a high proportion, and with a high bond strength to nucleic acid molecules. The solid support comprises a substrate and, provided thereon, an electrostatic layer for electrostatically attracting nucleic acid molecules and functional groups capable of covalently binding to nucleic acid molecules.

Solid support having electrostatic layer and use thereof

A method for determining the risk of adverse effects of irinotecan (CPT-11), a synthetic anticancer drug, by detecting polymorphisms in the TATA box within the promoter region of the UDP-glucuronosyl transferase gene. A kit for detecting the adverse effects of irinotecan containing at least one pair of nucleic acid probes.

Kits and method for determining the risk of adverse effects of irinotecan comprising hybridizing pairs of nucleic acid probes

It is intended to provide a method whereby DNA can be conveniently and rigidly immobilized on a substrate at such a high density as achieved by the conventional methods and a method of accurately detecting DNA. A substrate activation kit comprising a phosphate buffer (pH6), a solution A (an aqueous solution) of N-hydroxysuccinimide and a solution B (a dioxide solution) of 1-[3-(dimethylamino) propyl]3-ethylcarbodiimide; and a method of detecting DNA characterized by comprising spotting DNA on a substrate having been activated by using the above activation kit and then hybridizing the spotted DNA with fluorescence labeled DNA.

Substrate activation kit and method for detecting DNA and the like using the same

Growing community of inventors

Kudamatsu, Japan

Hiroshi Okamura