Kanebo, Limited

Hiroshi Ohtaka

Keizo Ito

Goro Tsukamoto

Takayuki Sukamoto

Toshiro Kanazawa

Kenji Suzuki

Manabu Hori

Kenji Yoshida

Tominori Morita

Ryuichi Iemura

Akira Yamashita

Yasuo Morimoto

Joji Maruo

Hideaki Hara

Yoichiro Hamada

Akio Ozaki

Sigeru Tajima

Kengo Harada

Koichi Shimohara

Ikuo Watanabe

Hisayoshi Tsutsui

Takeshi Yamamoto

A 1,4-benzoxazine derivative of the following formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed. The compound of the present invention is useful as a medicament for preventing or treating disorders induced by intracellular acidosis during myocardial ischemia, such as cardiac dysfunction, myocardial necrosis, arrhythmia, reperfusion injury, and the like, which are observed in ischemic heart diseases (e.g. myocardial infarction, angina pectoris, etc.).

1, 4-benzoxazine derivative and pharmaceutical compositions containing

Benzimidazole derivative, process for preparing the same, antiemetic

A quinazoline derivative represented by the following formula (I) ##STR1## or its pharmacologically acceptable acid addition salt and processes for production thereof. The quinazoline compound is used as a cerebral dysfunction remedying agent.

Quinazoline derivative, processes for its production, and cerebral

Novel piperazine compounds of the formula: ##STR1## wherein either one of R.sup.1 and R.sup.2 is methoxy group and another is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof, which have excellent anti-peptic ulcer activities with potent activity for promoting the action of the defensive factor, and hence are useful as an anti-ulcer agent for the prophylaxis and treatment of peptic ulcers.

Piperazine compounds and anti-ulcer composition containing the same

Novel benzylpiperazine compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, which has excellent hypolipidemic activity without undesirable side effect, and a pharmaceutical composition containing the compound as an active ingredient suitable for the prophylaxis and treatment of hyperlipidemia.

Benzylpiperazine compound and pharmaceutical composition as

A 1-benzhydryl-4-cinnamylpiperazine derivative represented by the following formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a methoxy group, and R.sup.2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The compound (I) is prepared by selectively reducing the corresponding 1-benzhydryl-4-cinnamoylpiperazine derivative and optionally converting the product into its acid addition salt. The compound (I) is useful for treatment of cerebrovascular disease in a human.

Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmaceutical

A 1-benzyl-4-benzhydrylpiperazine derivative represented by the following general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a methoxy group, and

1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are

Growing community of inventors

Osaka, Japan

Hiroshi Ohtaka