Yamasa Corporation

Tosoh Corporation

Hiroshi Ohrui

Hiroaki Mitsuya

Satoru Kohgo

Eiichi Kodama

Masao Matsuoka

Haruhiko Machida

Shiro Shigeta

Hiroshi Meguro

Kazuaki Akasaka

Kenji Kitano

The present invention provides a method for producing a 4'-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: wherein X represents a halogen atom, Rrepresents an ethynyl group or a cyano group, and Rrepresents hydrogen or a phosphoryl group. The present invention also provides the derivative, and a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. The derivative is useful as a medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).

4' -C-substituted-2-haloadenosine derivative

The present invention provides a 4'-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: wherein X represents a halogen atom, Rrepresents an ethynyl group or a cyano group, and Rrepresents hydrogen, a phosphate residue, or a phosphate derivative residue. The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. The derivative is useful as a medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).

4'-c-substituted-2-haloadenosine derivative

The present invention provides a 4'-C-substituted-2-haloadenosine derivative represented by the following formula [I], [II], or [III]: (wherein X represents a halogen atom, Rrepresents an ethynyl group or a cyano group, and Rrepresents hydrogen, a phosphate residue, or a phosphate derivative residue). The present invention also provides a pharmaceutical composition containing the derivative and a pharmaceutically acceptable carrier therefor. Such derivative is useful as medicine for the treatment of Acquired Immune Deficiency Syndrome (AIDS).

4'-C-substituted-2-haloadenosine derivative

4&prime;-C-ethynyl pyrimidine nucleosides and pharmaceutical compositions thereof

The invention provides 4&prime;-C-ethynyl purine nucleosides represented by formula &lsqb;I&rsqb;:

4&prime;-C-ethynyl purine nucleoside compounds

The invention provides 4&prime;-C-ethynyl pyrimidine nucleosides (other than 4&prime;-C-ethynylthymidine) represented by formula &lsqb;I&rsqb;:

4&prime;-C-ethynyl pyrimidine nucleoside compounds and pharmaceutical compositions

A method for analyzing a lipid peroxide, which comprises reacting a lipid peroxide with an aromatic phosphine compound of the formula: ##STR1## wherein each of R.sub.1 to R.sub.3 is an aromatic group, in a solvent, to form an aromatic phosphine oxide and observe any fluorescence of the aromatic phosphine oxide.

Method for analyzing lipid peroxides using aromatic phosphines

An aromatic phosphine compound of the formula: ##STR1## wherein each of R.sub.1 to R.sub.3 is an aromatic group, or an oxide thereof.

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Sendai, Japan

Hiroshi Ohrui