Yamanouchi Pharmaceutical Company Ltd.

Nippon Flour Mills Co., Ltd

Hiroshi Ogawara

Noriki Ito

Hideki Nakashima

Shunichi Watanabe

Keijiro Uchino

Naoki Yamamoto

Fukushi Hirayama

Hirokazu Yamamoto

Shigenobu Kadota

Akira Fukuchi

Masaya Iwamoto

Masashi Hiramoto

Sachie Murakami

Takashi Mizuno

The present invention provides a reverse transcriptase inhibitor and an antiviral agent comprising at least one member selected from the group consisting of sulfated tyrosines and physiologically acceptable salts thereof as an effective component; and exhibiting less toxicity and a remarkable inhibitory effect against a reverse transcriptase existing in viruses as well as a remarkable anti-AIDS viral activity.

Reverse transcriptase inhibitors and antiviral agents

Sulfated tannins or salts thereof are herein disclosed. These compounds can be prepared by a method which comprises reacting tannin with a sulfonating agent under a basic condition. These compounds show antiviral activity and reverse transcriptase inhibitor, effects and can be used to treat patients infected with a variety of virus such as AIDS virus, herpesvirus, influenza virus or rhinovirus.

Sulfated tannins and their salts

Novel isoflavone derivatives are provided which have the formula ##STR1## and which exhibit cancerocidal and immunosuppressive activity. The invention also provides pharmaceutical compositions containing the derivatives, methods of use and processes for their preparation.

Isoflavone derivatives, salts thereof, and oncostatic and

Isoflavone derivatives, and salts thereof, and cancerocidal and

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Tokyo, Japan

Hiroshi Ogawara