Funai Electric Company Ltd.

Sumitomo Chemical Company, Limited

Mitsubishi Tanabe Pharma Corporation

Sumitomo Pharmaceuticals Company Limited

The Japan Steel Works, Ltd.

Hiroshi Ochi

Hiroshi Noguchi

Tsutomu Yoshikawa

Yasuhiro Fujino

Masazumi Terashima

Hiroshi Ohtsuka

Shinichi Yokota

Masuhiro Kato

Kenji Irie

Setsuo Nakai

Ikuko Uezumi

An antibody has an antagonistic effect against IL-33. In particular an isolated human anti-IL-33 neutralizing monoclonal antibody has framework regions with amino acid sequences from a germline, including combinations and fragments of such sequences. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce the foregoing human anti-IL-33 neutralizing monoclonal antibodies having framework regions.

Human anti-IL-33 neutralizing monoclonal antibody

An object of the present invention is to provide an antibody having antagonistic effect against IL-33, in particular an isolated human anti-IL-33 neutralizing monoclonal antibody wherein amino acid sequences of framework regions are amino acid sequences that are amino acid sequences from a germline or a combination of amino acid sequences thereof, or a fragment thereof. The epitopes for a plurality of anti-IL-33 monoclonal antibodies were identified, human anti-IL-33 neutralizing monoclonal antibodies were obtained, and the complementarity-determining regions that achieve high binding ability to IL-33 was specified by introducing mutations in the complementarity-determining regions. The identified complementarity-determining regions were used to produce a human anti-IL-33 neutralizing monoclonal antibody having framework regions comprising amino acid sequences that are amino acid sequences of a germline or a combination of amino acid sequences thereof.

An optical disc recording and reproducing apparatus for recording and reproducing information on an optical disc with format other than video recording format, includes a record control portion that records apparatus information indicating the apparatus on a DVD and stores record elapsed time in a recording process and aspect information indicating an aspect ratio of a TV broadcasting program to be recorded in a memory of the apparatus when the TV broadcasting program is recorded on the DVD in a format except a; and a reproduction control portion that corrects the aspect ratio in accordance with the record elapsed time and the aspect information stored in the memory if the apparatus information recorded on the DVD matches the apparatus information stored in the memory, when the DVD is reproduced.

Optical disc recording and reproducing apparatus

When television screen setting is not set and thus a television screen setting completion flag is not set, and a terminals-connection judgment pin takes a low level, an i/p selection screen is initially displayed on a progressive display device. However, the i/p selection screen is not displayed on an interlaced display device. When processing performed for the i/p selection screen is completed, or when the terminals-connection judgment pin takes a high level, indicating that the video input D-terminal of the display device is not connected to the video output D-terminal, an aspect ratio setting screen is displayed. After aspect ratio setting is completed, the television screen setting completion flag is set. This eliminates the need to perform the television screen setting again.

Video signal output device

A first sound signal includes a first kind of sound signals and a second kind of sound signals. Chapter numbers are added to the first sound signal for respective switching of the kind of the sound. A second sound signal indicates a resulting sound signal after deletion of the second kind of sound signals from the first sound signal. A third sound signal indicates a sound signal in which remaining portions after deletion of the second kind of sound signals are combined with each other and chapter numbers are newly set. As described above, a chapter corresponding to a kind of a sound signal is added when the kind of the sound signal is switched, and a received signal is edited based on the chapter.

Recording apparatus for recording signal including a plurality of sound information

Both when disc reproducing means is performing a reproduction operation on a disc, and when the disc reproducing means is not performing a reproduction operation on a disc, a tray on which a rotary table is disposed can be moved by tray driving means to a accommodating position and a discharging position. In this configuration, when the disc reproducing means is performing a reproduction operation on a disc, the tray driving means moves the tray at a low speed (step S ), and, when the disc reproducing means is not performing a reproduction operation on a disc, the tray driving means moves the tray at a high speed (step S ).

Disc reproducing apparatus

A carousel type changer includes a disk reproducing section (a pickup and so on) which is provided on a tray and adapted to clamp a disk held on a disk holding part and to reproduce the clamped disk, and a disk recording section (a pickup and so on) which is provided separately from the tray , and adapted to clamp a disk held on a disk holding part when the tray is in a storing position and to record, on the clamped disk, signals reproduced by the disk reproducing section. In a state where the disk recording section have clamped the disk , a rotary table is allowed to rotate.

Carousel type changer

A human monoclonal antibody, which has prophylactic and therapeutic effect to infections diseases caused by Pseudomonas aeruginosa, and the epitope of which is located in the outer core moiety of LPS of the microorganism. A hybridoma producing the human monoclonal antibody, and processes for preparing the antibody and hybridoma are also provided.

Human monoclonal antibody and hybridoma producing the same

A human monoclonal antibody, which has prophylactic and therapeutic effect to infectious diseases caused by Pseudomonas aeruginosa of serotypes A and H classified under the Japanese Committee's Classification, and the epitope of which is located at the common structure in the O-antigen of Pseudomonas aeruginosa of serotypes A and H. A hybridoma producing said human monoclonal antibody, and processes for preparing said hybridoma and antibody are also provided.

Human monoclonal antibody, and its production and use

A method for removing unreacted monomer (or monomers) from an ethylene homopolymer or a copolymer of ethylene and at least one monomer copolymerizable with ethylene during the course of pelletization by use of an extruder, said polymer having been formed by high-pressure polymerization by use of a radiation or a radical initiator, discharged from the reactor by way of a separator, and fed to said extruder to be pelletized, which method comprises injecting into said extruder 0.1 to 10% by weight (based on said polymer) of water or steam intermixing the polymer and the water or steam in the mixing section of the extruder screw, and subjecting the resulting mix to a subatmospheric pressure of 500 mmHg (absolute) or less in the venting zone provided in the extruder. This method permits efficient removal of the unreacted ethylene or the unreacted ethylene and comonomer contained in a homopolymer or copolymer of ethylene.

Growing community of inventors

Osaka, Japan

Hiroshi Ochi