Takeda Chemical Industries, Inc.

Hiroshi Nara

Koji Yoshimura

Masayuki Takizawa

Toshiro Yamashita

The present invention provides a compound represented by Formula:wherein ring A and ring B may be same or different and each is an optionally substituted homocyclic or heterocyclic ring and the like, each Rmay be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group, an optionally substituted heterocyclic group or SR, etc., Xis a bond, an optionally substituted divalent Caliphatic hydrocarbon group or &#x2014;NR&#x2014;, etc, Xis a bond, an optionally substituted divalent Caliphatic hydrocarbon group, &#x2014;NR&#x2014;, &#x2014;O&#x2014; or &#x2014;S(O)&#x2014; (wherein p is 0, 1 or 2), each Y may be same or different and is a hydrogen atom, an optionally substituted hydrocarbon group, a halogen atom, a carboxyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, SR, an oxo group, a thioxo group, an optionally substituted imino group, a nitro group, a cyano group, etc., each m may be same or different and is 0 or 1, n is an integer of 1 to 3, qis an integer of 1 to 2n+4, qis an integer of 0 to 2n+3, and the sum of qand qis 2n+4 or a salt thereof.

Thiol compounds, their production and use

Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R s are the same or different and each represents hydrogen, optionally substituted hydrocarbyl, acyl, etc.; X represents a bond, optionally substituted divalent aliphatic hydrocarbyl, etc.; X represents a bond, optionally substituted divalent aliphatic hydrocarbyl, &mdash;O&mdash;, etc.; Ys are the same or different represents hydrogen, optionally substituted hydrocarbyl, oxo, etc.; m is 0 or 1; n is an integer of 1 to 3; q is an integer of 1 to 2n&plus;4; and q is an integer of 0 to 2n&plus;3, provided that q &plus;q is 2n&plus;4.

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Suita, Japan

Hiroshi Nara