Myriad Genetics, Inc.

Itherx Pharmaceuticals Inc.

Itherx Pharma, Inc.

Hiroshi Nakanishi

Jan Urban

Robert W Sullivan

Antonio Garrido Montalban

Justin T Ernst

Christopher Larson

Russell Dahl

Erik Boman

Susana Conde Ceide

Nancy G J Delaet

Zhinjun Wang

Masakatsu Eguchi

Zhijun Wang

Edward Roberts

Jeffrey Dean Kahl

Min Sang Lee

Eddine Saiah

Hwa-Ok Kim

Stephen F Miller

Gangadhar Nagula

Jessymol Mathew

Christopher Lum

Vincent Huber

Stephen Miller

Robert Sullivan

Jeffrey D Kahl

Antonio G Montalban

Justin Ernst

Susana Conde-Ceide

The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.

Cytokine inhibitors

Alpha-ketoamides and derivatives thereof

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed: wherein A, R, R, Rand Rare as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.

Reverse-turn mimetics and compositions and methods related thereto

Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, Rand Rare as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) antagonists. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening such libraries to identify biologically active members.

Helix mimetics and composition and methods related thereto

Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed:wherein A, B, X, R, and Rare as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.

Reverse-turn mimetics and methods relating thereto

Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure:including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, Rand Rare as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) antagonists. Libaries contaning the compounds of this invention are also disclosed, as well as methods for screening such libaries identify biologically active members.

Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins having the following structure are disclosed:wherein A, R, R, Rand Rare as defined herein. Such compounds have utility over a wide range of fields, including use as diagnostic and therapeutic agents. In particular, compounds of this invention are useful in pharmaceutical compositions as anti-inflammatory agents as well as inhibitors of central nervous disorders. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening the same to identify biologically active members.

Reverse-turn mimetics and composition and methods relating thereto

Growing community of inventors

San Diego, CA, United States of America

Hiroshi Nakanishi