Chugai Seiyaku Kabushiki Kaisha

Hiroshi Nakakimura

Yasushi Murakami

Shun-Ichi Hata

Masuo Koizumi

Yukifumi Noda

Kazuo Sasahara

Tomohiro Neichi

Takashi Mori

Noboru Kubodera

Sakae Takaku

Tamotsu Yamazaki

Takashi Matsuno

Shigeyuki Kataoka

Masamitsu Honda

Hiroshi Matsushita

Shigeru Takanashi

Fumiaki Matsuura

Sakae Wada

Dibenzoxazepine derivatives of the formula: ##STR1## wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the description, process for preparing the same, pharmaceutical composition containing the same and method of treating diseases in circulatory organs administering the composition to a patient are disclosed. The compounds of the formula have lipid lowering activity, lipid peroxide lowering activity, blood sugar lowering activity and activity to inhibit the aggregation of platelets, and hence are useful as a medicine.

Dibenzoxazepine derivative, and pharmaceutical composition comprising

Novel compound, 1,2-bis(nicotinamido)propane and its pharmaceutically acceptable salts, a process for preparing the same and a pharmaceutical composition containing the same as an active ingredient are disclosed. The compound acts to prevent or spasmolyse cerebral vasospasms, to prevent cerebral apoplexy and to lower the lipoperoxide level in blood.

Nicotinamide derivative, process for preparing the same and

Dibenz[b,f][1,4]oxazepine derivatives represented by the formula ##STR1## [wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the specification], and a process for preparing the same are disclosed. The object compounds have excellent serum cholesterol lowering activity, serum lipid lowering activity, blood lipid peroxide lowering activity and anti-aggregation of platelet activity, and therefore are useful as a drug.

Benzoxazepine derivatives and process for preparing the same

Growing community of inventors

Kamakura, Japan

Hiroshi Nakakimura