Meiji University

Pormedtec Co., Ltd.

United States of America, As Represented by the Secretary of Agriculture

Showa Ika Kogyo Co. Ltd.

Bios Co., Ltd

Hiroshi Nagashima

Hitomi Matsunari

Eiji Kobayashi

Takashi Yokoo

Mamoru Aizawa

Masahiro Rikukawa

Yusuke Shigemitsu

Masahito Watanabe

Koki Hasegawa

Ayuko Uchikura

John R Dobrinsky

Kazuaki Nakano

Disease model pigs produced by nuclear transplantation, disease model pigs exhibiting stable phenotypes and production methods thereof are provided. Chimeric pigs for producing disease model pigs exhibiting stable phenotypes, genital glands thereof, and germ cells thereof are also provided. A method for producing a genetically modified disease model pig, includes: (a) transplanting a nucleus of a genetically modified cell into cytoplasm of an egg; (b) developing an obtained clonal embryo in a womb of a female pig to obtain an offspring; and mating the obtained offspring or having the offspring undergo sexual reproduction to further obtain the genetically modified offspring as a disease model pig.

Disease model pig exhibiting stable phenotype, and production method thereof

Provided is a method for developing a secondary organ by using a non-human animal in which organ formation is inhibited, for the purpose of establishing a process for producing a functional cell such as a &#x3b2; cell within the body of an animal such as a pig, the method including the step of raising a newborn or a fetus of the non-human animal in which organ formation is inhibited by complementing at least a part of the function of the organ whose formation is inhibited.

Method for developing organ that lacks specific functional cell

An organ for transplantation having a kidney, a ureter, and a urinary bladder and an organ structure in which a first ureter, a first urinary bladder, a second ureter and a second urinary bladder are sequentially connected to a kidney can produce urine and excrete the produced urine, and thus is useful for transplantation.

Organ for transplantation and organ structure

Provided are 1) a hollow fiber cryopreservation instrument having a long support on which a hollow fiber is placed, wherein the support is formed of a low-temperature-resistant material, and 2) a cell cryopreservation method having a process of placing a hollow fiber on the support of the hollow fiber cryopreservation instrument, and a process of cryopreserving cells in a state in which the hollow fiber is placed on the support.

Hollow fiber cryopreservation instrument and cell cryopreservation method

A hydroxyapatite ceramic hybrid material, which includes a biodegradable polymer included in the pores in a hydroxyapatite ceramic structure, and a method thereof, and a calcium phosphate porous body, which is formed by an intertwining of fibrous calcium phosphates and includes a plurality of first pores formed where the fibrous calcium phosphates interconnect and plurality of equal diameter substantially spherical second pores with a larger inside diameter than the first pores, and a method thereof are provided.

Biocompatible ceramic-polymer hybrids and calcium phosphate porous body

A method for the cryopreservation of zona pellucida-intact, early-stage swine embryos, morulae and blastocysts includes centrifuging the embryos prior to cryopreservation in order to remove intracytoplasmic lipids. The lipids are localized external to the embryo proper inside the zona pellucida, thus neutralizing harmful effects which prevent subsequent embryological development. The embryos may be cryopreserved by vitrification or conventional freezing. After recovery and rehydration, zona pellucidae are removed, and intact, viable embryos are transferred to recipient females.

Growing community of inventors

Kawasaki, Japan

Hiroshi Nagashima