Takeda Pharmaceutical Company Limited

Toray Industries, Inc.

Hiroshi Nagabukuro

Yuji Ishihara

Takayuki Doi

Yuji Ishichi

Naoyuki Kanzaki

Motoki Ikeuchi

Tsuneo Oda

Masato Yoshida

Takahiro Matsumoto

Naoki Izumimoto

Kuniaki Kawamura

Osamu Kurasawa

Tadatoshi Hashimoto

Yasuhisa Kohara

Toshikazu Komagata

Tomohiko Suzaki

Manabu Mochizuki

Haruhiko Kuno

Reiko Saikawa

Yuuichi Okabe

Shigemitsu Imai

An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen containing heterocyclic group, such as compound 1: 

Analgesic and methods of treating pain

Provided are an iminopyridine derivative having a selective &#x3b1;adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like, and a screening method for a compound having an &#x3b1;adrenergic receptor antagonistic action. An &#x3b1;adrenergic receptor antagonist containing a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof, and a method of screening for an agent having an &#x3b1;adrenergic receptor antagonistic action for the prophylaxis or treatment of a lower urinary tract disease, which includes measuring the bladder smooth muscle tension of rats with bladder outlet obstruction.

Iminopyridine derivative and use thereof

Agents for improving potency of the urinary bladder which comprise an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action. Particularly, crystals of a tricyclic, condensed, heterocyclic derivative are provided, which possess an excellent action to inhibit acetylcholinesterase and an action to improve the excretory potency of the urinary bladder. As an example, crystals of 8-[3-[1-[(3-fluorophenyl)-methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one or a salt thereof and pharmaceutical compositions containing them are disclosed.

Agents and crystals for improving excretory potency of urinary bladder

A novel pyrrolopyridine derivative which is a compound represented by the formula  wherein Ring A represents an optionally substituted pyridine ring; X represents an electron-attracting group; Y represents an optionally substituted divalent Cchain hydrocarbon group; Rrepresents an optionally substituted hydrocarbon group; and Rand Reach independently represents hydrogen, an optionally substituted hydrocarbon group or an optionally-substituted heterocyclic group, or Rand Rmay form an optionally substituted ring in cooperation with the adjacent nitrogen atom, or a salt of the compound. The pyrrolopyridine derivative has vanilloid receptor agonist activity and is useful as medicines such as a preventive/therapeutic agent and analgesic for overactive bladder.

Pyrrolopyridine derivative and use thereof

Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an &#x3b1;1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.

Preventives/remedies for urinary disturbance

Growing community of inventors

Osaka, Japan

Hiroshi Nagabukuro