Tanabe Seiyaku Company, Limited

Mitsubishi Tanabe Pharma Corporation

Sumitomo Precision Products Co., Ltd.

Daiichi Fine Chemical Co., Ltd.

Hiroshi Morimoto

Kenji Arakawa

Kosuke Yasuda

Takeshi Matsumoto

Masataka Hikota

Saburo Kawanami

Kazunari Tada

Koichi Wada

Keiji Sakamoto

Yasuto Onomichi

Hajime Ito

Harutami Yamada

Jun Kotera

Taketoshi Ishii

Takeo Kitazawa

Nobuhiro Take

Fumio Maniwa

Yukiko Shimmoto

Takashi Sasaki

Takeshi Otani

A landing gear assembly includes a control system configured to output an amount of operation corresponding to an operated physical amount; a wheel; a landing gear supported by a frame of the aircraft, and configured to rotatably support the wheel; a steering system configured to steer the wheel using the amount of operation as a command value; and a detection sensor configured not to output a detection signal when the aircraft flies in air, and to output the detection signal when the aircraft stays on ground. When the detection sensor does not output the detection signal, or when speed of the aircraft is higher than first limitation speed, the steering system orients rotation of the wheel in a longitudinal direction of the aircraft in disregard of the amount of operation.

Landing gear assembly of aircraft

The present invention relates to a therapeutic or prophylactic method for treating Parkinson's disease by administering an effective amount of a compound having a phosphodiesterase 10 inhibitory activity; and also relates to a pharmaceutical composition for treatment or prophylaxis of Parkinson's disease comprising as an active ingredient a compound having a phosphodiesterase 10 inhibitory activity. Moreover, the present invention relates to a method for enhancing dopamine signal in the brain, which comprises administering an effective amount of a compound having a phosphodiesterase 10 inhibitory activity; and also relates to pharmaceutical composition for enhancing dopamine signal in brain comprising as an active ingredient a compound having a phosphodiesterase 10 inhibitory activity.

Treatment of Parkinson's disease and enhancement of dopamine signal using PDE 10 inhibitor

A compound represented by the following general formula (I) or a salt thereof: wherein Rrepresents a glycosyl group, a phosphate group, or a cyclic phosphate group bound to R; Rrepresents &#x2014;CHOH, &#x2014;CHO, &#x2014;CHNH, &#x2014;CH-amino acid residue, or &#x2014;CH&#x2014;OPOH; and Rrepresents hydrogen atom, or &#x2014;POH, and a composition for cosmetics, medicaments, foodstuffs, and/or feeds containing the aforementioned compound or a salt thereof.

Stable vitamin B6 derivative

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: 

Nitrogen-containing 5-membered ring compound

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings;

Aliphatic nitrogen-containing 5-membered ring compound

Nitrogenous 5-membered ring compounds

The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]:wherein

Aliphatic nitrogenous five-membered ring compounds

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Saitama, Japan

Hiroshi Morimoto