Morinaga Milk Industry Co., Ltd.

Other

Toray Industries, Inc.

Hiroshi Miyakawa

Hitoshi Saito

Seiichi Shimamura

Mamoru Tomita

Yoshitaka Tamura

Yasushi Kawaguchi

Susumu Kobayashi

Hiroshi Ochi

Hiroaki Abe

Akio Yamada

Hirotoshi Hayasawa

Mitsunori Takase

Koji Yamauchi

Yasuo Fukuwatari

Naoko Isomura

Yoko Akazome

Mihoko Kawamoto

Kouzou Kawase

Shigeo Okonogi

Toshio Takeuchi

Tsutomu Kudo

Norio Ishibashi

Toshio Tomimura

Shuzo Ishida

Tomoko Ide

Koki Ueno

Hideo Umeuchi

Eiji Nagao

Koichi Sugawara

Hirokatsu Kanehara

Waichi Ishizuka

Naomichi Okuma

Eri Inoue

Toshikazu Shichino

An antipruritic against pruritus caused by multiple sclerosis is disclosed. The antipruritic comprises as an effective ingredient an &#x3ba; opioid receptor agonist compound having a 4,5-epoxymorphinan skeleton and having a specific chemical structure, such as Compound 1 having the following structure: 

Antipruritic agent for pruritus caused by multiple sclerosis

A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs.

Peptide having angiotensin converting enzyme inhibitory effect

A protein hydrolysate comprising at least two types of peptides, characterized in that the rate of hydrolysis of protein is from 30 to 45%, the number average molecular weight is 300 or less, and the ratio of a weight average molecular weight to the number average molecular weight is greater than 1 and 2 or less, has excellent emulsifiability, and antigenicity thereof is low enough to be used for people who has predisposition to allergic diseases. This protein hydrolysate is obtained by hydrolysis of a protein starting material to a rate of hydrolysis in the range of 30 to 45%, and then bringing it into contact simultaneously or separately with two types of porous synthetic adsorbent respectively having an average pore radius of 2 to 8 nm and an average pore radius of 20 to 30 nm, the total surface area of the two porous synthetic adsorbents being in a range of 300 to 3000 mper 1 g (protein equivalent) of the obtained protein hydrolysate, and recovering the non-adsorbed component.

Protein hydrolyzates, process for producing the same and drinks and foods containing the protein hydrolyzates

A method for producing a peptide mixture from a starting protein by (1) adding at least one protease to an aqueous solution of at least one starting protein to hydrolyse the starting protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the starting protein, (3) calculating the amount of the free amino acid with respect to the total amount of amino acid contained in the starting protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the starting protein falls within a predetermined range. The inventive method provides a starting protein hydrolysate of uniform and consistent quality.

Peptide mixture and products thereof

Fine granular feeds for fry of fishes and shellfishes capable of remarkably elevating the survival rate of fry, improving the cultivation efficiency, and causing little elution of nitrogen sources therefrom into seawater or water in feeding, which are characterized by containing at least three active components, i.e., (a) a long-chain unsaturated fatty acid calcium salt blend comprising 80% by weight or more of long-chain unsaturated fatty acid calcium salt(s) having at least 18 carbon atoms, (b) 20% by weight or less of a browned matter formed by heating molasses or saccharides, a browned matter formed by heating saccharides with amino acids or a mixture thereof at an arbitrary ratio, and (c) a mixture of peptides obtained by hydrolyzing animal protein, and being in the form of fine grains.

Fine granular feeds for fry

Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

Lactoferrin hydrolyzate for use as an antibacterial agent and as a

A method for treatment of a matter which contains moisturized or liquified lactoferrin which has been isolated from mammalian milk, processed mammalian milk and by-products in mammalian milk-processing, without losing the physiological activities of lactoferrin, which comprises adjusting pH of said moisturized or liquefied lactoferrin contained in said matter within an acidic range between 2.0 and 6.0 both inclusive by adding acid or aqueous solution of acid when the pH of said moisturized or liquefied lactoferrin is out of said pH range, and heating said matter in the range from 60.degree. C. to 130.degree. C. for a span of time which may assure 60% or more of undenaturization rate of lactoferrin.

Method for heat treatment of lactoferrin without losing physiological

Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.

Bioactive agents, compositions and materials comprising said bioactive

Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.

Bioactive agents and compositions for materials comprising the bioactive

An agent for tyrosinase inhibition which contains the effective quantity of enzymatic hydrolyzates of milk proteins, having a decomposition rate from 6% to 55% as expressed by the percentage of formol nitrogen to total nitrogen.

Method for inhibiting tyrosinase activity in treatment of skin

Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

A composition of feedstuff containing at least 0.5 wt. %, in solid content, of residual liquid of incubated culture broth of Bifido-bacteria and/or lactic acid bacteria which residual liquid is obtainable as the waste by-product of mass production of living or viable cell mass of the microorganisms by substantially excluding microbial cell mass from the incubated culture broth thereof.

Composition of feedstuff

Growing community of inventors

Kamakura, Japan

Hiroshi Miyakawa