Taiho Pharmaceutical Company Limited

Synphar Laboratories, Inc.

Hiroshi Matsumoto

Tomohiro Yamashita

Toshio Otani

Rajeshwar Singh

Ronald J Micetich

Shinji Oie

Setsuro Fujii

Mitsugi Yasumoto

Setsuo Takeda

Norio Unemi

Tadafumi Terada

Charles Y Fiakpui

Chan M Ha

George Thomas

Jun-ichi Yamashita

Toru Sasaki

Toshiyuki Toko

Singh Rajeshwar

Zhang J Liang

Mark Tempest

Takashi Kawauchi

Ming-Yu Huang

Ru-Xian Chen

Ken-ichiro Yoshida

Zhang Q Rong

Zhen J Sheng

Zhang Z Ping

3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives

Substance IT-62-B and medicinal composition containing the same

3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as

A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a benzoyl group optionally having one or more substituents or a benzyl group optionally having one or more substituents, R.sub.2 is a hydrogen atom or a carboxyl-protecting group, R.sub.3 is a hydroxyl group, an azido group, a benzenesulfonyloxy group optionally having one or more substituents, a lower alkylsulfonyloxy group optionally having one or more substituents, a tri-substituted silyloxy group or an amino group optionally having one or more substituents, provided that when R.sub.1 and R.sub.2 are hydrogen atoms, R.sub.3 is not an amino group, and a salt thereof.

3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid

4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents

Novel 2'-deoxy-5-substituted uridine derivative represented by the general formula, ##STR1## wherein R.sub.1 is a hydrogen atom, a benzoyl group or a tetrahydrofuranyl group; R.sub.2 is a fluorine atom or a trifluoromethyl group; and any one of R.sub.3 and R.sub.4 is a hydrogen atom and the other one is an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, a benzyl group having as the substituents selected from the group consisting of a halogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms and a nitro group, or an alkyl group having 1 to 3 carbon atoms having one or two phenyl groups as the substituents. The novel 2'-deoxy-5-substituteduridine derivative possesses excellent antitumor activity with less toxicity, thus it is useful as antitumor agent.

2'-deoxy-5-substituted uridine derivatives

Novel 2'-deoxy-5-substituted uridine derivatives, processes for

Growing community of inventors

Tokushima, Japan

Hiroshi Matsumoto