Kureha Chemical Industry Company, Limited

Daiichi Sankyo Company, Limited

Hiroshi Maruoka

Toru Yamazaki

Mikiro Yanaka

Seiichi Imajo

Taisaku Tanaka

Tsuyoshi Muto

Yoshiaki Tomimori

Hiroshi Takahashi

Shigeru Suzuki

Hiroyuki Enari

Michihito Ise

Fuyuhiko Nishijima

Toshikazu Dewa

Koji Sato

Naoki Yamamoto

Koichi Niimura

Tsutomu Yagi

Koju Watanabe

Kunitaka Hirose

Mikio Sugano

Tsutomu Mukade

A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

7-membered ring compound and method of production and pharmaceutical application thereof

The present invention provides novel compounds having antiviral activities and antiviral drugs containing the compounds as the active ingredient. The compounds are shown by the following general formula (1),wherein typically Aand Aare each guanidine or a group of the general formula (ia); Ais a mono- or poly-cyclic heteroaromatic ring containing 1 or 2 heteroatoms; Bis a single bond or alkylene group; Ris hydrogen or alkyl group; W is an alkylene having 2-3 carbons, a cycloalkylene having 5-10 carbons, aromatic ring having 6-10 carbons, or a heteroaromatic ring having 5-10 carbons; y is C(&#x2550;O)&#x2014;; x is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;; nis an integer of 1-2; nis an integer of 2-3; D is a substituent selected from among various groups

Nitrogenous compounds and antiviral drugs containing the same

Benzimidazole derivative

An aromatic compound of the formula (I): ##STR1## specifically, for example, 3-��(4-carboxyphenyl)methyl!valeramido!-4-dimethylaminobenzoic acid 4'-methylpiperazide, or a salt thereof, and a pharmaceutical composition comprising said aromatic compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent which provides sufficiently effective alleviation of renal dysfunction without affecting blood pressure at a low blood concentration.

Aromatic compound and pharmaceutical composition

A compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, --CON(R.sup.4)R.sup.5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R.sup.1 and R.sup.2 is --CON(R.sup.4)R.sup.5, and R.sup.4 and R.sup.5 are, independently, a hydrogen atom, or a hydroxyl, alkyl, aryl, or aralkyl group, or R.sup.4 and R.sup.5 together with the nitrogen atom attached thereto form a 3- to 7-membered saturated cycloaliphatic amino group, and R.sup.3 is a hydrogen atom, or a hydroxyl, alkyl, aryl, aralkyl, or --COOR.sup.8 group, and R.sup.3 is at 3- or 4-position, and R.sup.8 is a hydrogen atom or an alkyl group, or a salt thereof is disclosed. The compound has a function to inhibit a matrix metalloproteinase.

Esculetin derivatives, method for manufacture thereof, and

Growing community of inventors

Osaka, Japan

Hiroshi Maruoka