Kao Corporation

Kao Coproration

Hiroshi Kusuoku

Shigeru Moriwaki

Atsushi Ohuchi

Mitsuyoshi Sakasai

Shingo Kakuo

Genji Imokawa

Katsutoshi Ara

Akira Yamamuro

Naoko Tsuji

Yukihiro Yada

Mayumi Sato

Masahide Hoshino

Taketoshi Fujimori

Kazuhiko Higuchi

Toyoki Hagura

Kentaro Kumihashi

Takashi Kitahara

Shunichi Akiba

Etsuji Wakisaka

Tomohiro Shirai

Hiroshi Hashimoto

Yukihiro Ohashi

Akira Kawamata

Yoshinori Nishizawa

Tsutomu Fujimura

Yoshinori Takema

Yoshiya Sugai

Ichiro Tokimitsu

Minoru Nagai

Tadashi Hase

Koji Yoshino

Shinobu Mori

Ayumi Ogawa

Koichi Murayama

Youichi Arai

Minoru Takizawa

Atsuko Otsuka

Hiroyuki Ohsu

Syunichi Akiba

Akira Fuji

Hisashi Tsujimura

Hajime Tokuda

Yoshinori Masukawa

Naoki Kondo

Shinichi Meguro

Kiyoko Sugino

The present invention provides a processed plant product having an excellent TRPM8 activating action, a method for producing the same, and a cooling agent and a TRPM8 activator comprising the processed plant product. A method for producing a processed nutmeg product, comprising a step of simultaneously treating nutmeg or an extract thereof with an alcohol or a 25% (v/v) or more alcohol aqueous solution and one or more selected from a protonic acid and an H-type cation exchange resin.

Processed nutmeg product and method for producing same

Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein Rrepresents a hydrogen atom; Rrepresents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or a hydroxyl group; Rrepresents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and Rrepresents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

Cooling agent and TRPM8 activator

A method of increasing expression of the aromatase gene by treating a cell population with an effective amount of an aromatase activator containing an extract of, where the effective amount ranges from 0.0001 to 1% by weight based on the total weight of the aromatase activator on a dry basis.

Aromatase activator

Deodorant agents, which containorBark or its extract as an active ingredient and which are high in safety and can radically inhibit the emission of human body malodors typified by sweat odor, especially, axillary odor.

Deodorant agent

To provide a lipolysis agent, a slimming agent, and a cellulite-ameliorating agent, which stimulate decomposition of fat accumulated in the adipose tissue, to thereby exhibit body-slimming effect and which is effective for inhibition or prevention of obesity and amelioration of prone to obesity. The lipolysis stimulator of the invention contains, as effective ingredients, a plant Huang Hua Cai or an extract thereof, and a xanthine derivative.

Lipolysis stimulator

Drugs and cosmetics which are highly safe, and which are effective in preventing, improving, or treating various pathological conditions caused by estrogen depletion are provided. Provided are aromatase activators containing at least one member selected from plants such as Labiatae sps. including(huangcen),(jingjie), sage, lavender,, and thyme, an extract thereof; yeast extract; silk protein extract; milk protein; trehalose; natto extract; royal jelly;oil; hydrolyzated wheat extract; shea butter; and rice fermentation extract.

The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected from Bupleuri Radix, Perillae Herba, Rhei Rhizoma and Akebiae Caulis, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.

Hair growth inhibitor and depilation accelerator

Provided is a deodorant composition containing (A) an extract of a plant selected from phellodendron (or), ginkgo (),, licorice () and gardenia (), and (B) an unsaturated fatty acid. This deodorant composition has benefits such as an excellent deodorant effect and even if it contains powder, it does not leave substantially any white residue on the skin.

Deodorant composition

The present invention relates to a hair growth inhibitor and a depilation accelerator, each comprising a crude drug selected fromand, or an extract thereof. This inhibitor or accelerator makes it possible to inhibit the growth of body hair or promote depilation, respectively, thereby reducing the frequency of hair removal treatment. Moreover, it makes the hair body finer, thereby facilitating the removal of the hair from feet or arms.

Herbal hair growth inhibitor and depilation accelerator

A lipolysis stimulator and a slimming agent which stimulate or facilitate lipolysis of accumulated adipose tissue, to thereby exert the body slimming effect. The lipolysis stimulator or the slimming agent of the present invention contains as an active ingredient any form of a plant or an extract thereof, the plant being selected from among common juniper, togenashi, rosehip,root,herb,, zuikorodoku, garden, kidachiumanosuzukusa, bayberry, cogon grass, kohon, shoyokanzo, Japanese white birch, tanjin, kikubafuro, white mustard, common sunflower, ground ivy, Chinese wolfberry, Japanese pagota tree, sennenken, common fig, kankatto, Chinese hibiscus, usubaakaza, fenugreek, English walnut, sozuku, koniwa-zakura,, shima-kan-giku, akamino-akane, futaba-mugura, karoou, schizonepeta spike, purslane, karabyakushi, and prostrate knotweed.

The present invention is directed to an aromatase activating agent containing a plant selected from among mulberry bark, ginseng, cucumber, andbark; or; or an extract of any of these ingredients. The aromatase activating agent of the present invention is highly safe to the human body, and useful as a drug or cosmetic composition for prevention, amelioration, or treatment of various lesions caused by estrogen deficiency.

Method for treating lesions caused by estrogen deficiency with extract of cucumber

The invention contemplates drugs useful for maintenance or promotion at sites of regenerating nerves and for prevention or treatment of pathological conditions caused by denaturation or cell damage in the nervous system. Thus, the invention provides an apolipoprotein D degradation inhibitor containing lauric acid or oleic acid as an active ingredient.

Apolipoprotein D degradation inhibitor

Amide derivatives and external skin or hair care preparations

Amine derivatives for treatment of skin disorders

An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.

Amide derivatives and their use in cosmetic composition

Growing community of inventors

Tochigi, Japan

Hiroshi Kusuoku