Osaka University

Anges, Inc.

Anges Mg, Inc.

Kinyosha Co., Ltd.

Ds Pharma Animal Health Co., Ltd.

Hiroshi Koriyama

Ryuichi Morishita

Hironori Nakagami

Akiko Tenma

Futoshi Nakagami

Hideki Tomioka

Yoshiharu Ogawa

Munehisa Shimamura

Mariko Kyutoku

Kenji Naohara

Natsuki Yoshida

Yuka Ikeda

The present invention provides a preventive or therapeutic method for an inflammatory skin disease, such as psoriasis, the method comprising administering an oligopeptide as an active ingredient. More specifically, the invention provides a preventive or therapeutic method for an inflammatory skin disease, the method comprising administering an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a &#x3b2;-strand D sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.

Preventive or therapeutic method for inflammatory skin disease

The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.

Treatment of IL-17A diseases

The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains

DNA-peptide combination vaccine

The invention provides a peptide and an immunostimulant or hair grower containing the peptide as an active ingredient, as well as a method for hair growth or regrowth promotion by administering an effective amount of the peptide to a mammal. The peptide has 23 or less amino acids and includes the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9).

Peptide and use thereof

An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.

The present invention provides an agent for the treatment or prophylaxis of arteriosclerosis comprising an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of apolipoprotein (a), wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.

DNA vaccine containing specific epitope of apolipoprotein (a)

The present invention provides a therapeutic or improving agent for a lifestyle-related disease, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of the lifestyle-related disease-related factor, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.

DNA vaccine

The present invention provides a rubber blanket for an offset printing, comprising a surface rubber layer, a first fabric layer, a compressible layer and a second fabric layer, wherein the thickness of the blanket falls within a range of between 1.65 mm and 3 mm, the first fabric layer is a plain weave having a thickness falling within a range of between 0.2 mm and 0.35 mm, the second fabric layer is a plain weave having a thickness falling within a range of between 0.35 mm and 0.55 mm, a tensile strength not lower than 50 kgf/cm, and an elongation at break not higher than 7.5%, and the compressible layer has a thickness falling within a range of between 0.5 mm and 2.15 mm.

Growing community of inventors

Suita, Japan

Hiroshi Koriyama