Daiichi Pharmaceutical Co., Ltd.

Daiichi Seiyaku Co., Ltd.

Hiroshi Korenaga

Kazuhiro Inoue

Noriko G Tanaka

Hiroshi Kuga

Hidemasa Ogawa

Yoshinobu Shiose

A drug delivery system compound comprising a carboxy(C )alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C )alkyldextran polyalcohol, and a method for measuring a drug delivery system compound in which a polymer carrier and a residue of drug compound are bound to each other by a spacer comprising 2 to 8 amino acids linked by peptide bond(s), which comprises treating the drug delivery system compound with a peptidase, and measuring the resulting hydrolysate.

DDS compounds and method for assaying the same

A sulfated polysaccharide DS4152 useful as an angiogenesis inhibitor or antitumor agent is provided selectively. As the sodium salt, it has the following physicochemical characteristics. Molecular weight by the gel filtration method: 29,000.+-.3,000. Elemental analysis: C: 24.42-25.76%, H: 3.34-3.98%, N: 0.51-0.89%, S: 10.6-11.7% and P: 0.77-1.06%. Sugar and protein contents: Sugar content (%): 57.+-.3 (by phenol sulfuric acid method; standard: galactose). Protein content (%): 1.+-.0.5 (by the Lowry-Folin's method; standard: bovine serum albumin). Specific rotatory power [.alpha.].sub.D.sup.25 : -37.degree..+-.1.degree. (0.5% aq. solution). Characteristic absorption bands in infrared absorption spectrum: 1240, 840 (shoulder), 810 (cm.sup.-1 ; KBr).

Sulfated polysaccharide DS4152

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Chiba, Japan

Hiroshi Korenaga