Riken Corporation

Other

Institute of Biotechnology Applied To Soil Eumycetes

Hiroshi Konno

Hiroyuki Osada

Hideaki Kakeya

Susumu Kanazawa

A compound represented by the following formula (I) or a salt thereof which has excellent antitumor activity and angiogenesis inhibitory action in a low oxygen condition, and a medicament such as an antitumor agent and an anti-inflammatory agent which comprises the compound or a physiologically acceptable salt thereof as an active ingredient. 

Substance having antitumor/anti-inflammatory activity

A compound represented by formula (I) wherein Rrepresents hydrogen atom and Rrepresents hydroxyl group, or Rand Rmay combine together to represent oxo group or oxime group; Rrepresents hydrogen atom and Rrepresents hydroxyl group, or Rand Rmay combine together to represent oxo group or oxime group; Rrepresents hydrogen atom and Rrepresents hydroxyl group, or Rand Rmay combine together to represent oxo group or oxime group; Rrepresents hydrogen atom and Rrepresents hydrogen atom, or Rand Rmay combine together to represent oxo group or oxime group; Rand Rrepresent hydrogen atom, an alkyl group, or an alkenyl group. The compound is useful as an active ingredient of a medicament having angiogenesis suppressive activity, apoptosis suppressive activity, and cell cycle inhibitory activity 

PKB-3564 substance with neovascularization inhibitory activity

A compound represented by the following formula (I) or a salt thereof and a medicament such as an angiogenesis inhibitor and an antitumor agent which comprises said compound or a physiologically acceptable salt thereof as an active ingredient.

Growing community of inventors

Akita, Japan

Hiroshi Konno