Kabushiki Kaisha Yakult Honsha

Hiroshi Kodaira

Seigo Sawada

Hideaki Shimizu

Atsuhiro Abe

It is intended to provide a novel compound that has an excellent &#x3b3;-secretase inhibitory effect and specifically inhibits A&#x3b2; production. The present invention provides a compound of the following formula (1) or a pharmaceutically acceptable salt thereof: wherein Rrepresents a linear or branched alkyl group having 1 to 4 carbon atoms or a phenyl group; Rrepresents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more phenyl or halogenophenyl groups; Rrepresents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more hydroxyl groups; Rrepresents a linear or branched alkyl group having 1 to 4 carbon atoms; and the symbol '*' represents a chiral center. 

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Minato-ku, Japan

Hiroshi Kodaira