Tdk Corporation

The University of Tokyo

Sae Magnetics (h.k.) Limited

The Uab Research Foundation

University of Alabama

Hanavax Inc.

Tokyo Medical and Dental University

Intellectual Property Strategy Network, Inc.

Hiroshi Kiyono

Yoshikazu Yuki

Nozomu Hachisuka

Shunji Saruki

David E Briles

Kenji Inage

Tomohito Mizuno

Takeo Kagami

Tetsuya Kuwashima

Larry S McDaniel

Tetsuo Miyazaki

Yong Shen

Kwok Kam Leung

Masafumi Yamamoto

Koji Shimazawa

Takahiro Mori

Noriaki Kasahara

Katsuki Kurihara

Yosuke Antoku

Satoshi Tomikawa

Kazunari Akiyoshi

Nobutaka Nishio

Yosuke Kurashima

Rika Nakahashi

Hiraku Hirabayashi

Kei Hirata

Naoki Ohta

Kenzo Makino

Kazumasa Fukuda

Tsuyoshi Umehara

Norio Takahashi

Noboru Yamanaka

Katsumichi Tagami

Tatsushi Shimizu

Takamitsu Sakamoto

Makoto Moriya

Kenkichi Anagawa

Nobuya Oyama

Ken-ichi Takano

Hiroki Matsukuma

Seiji Yari

Yoshikazu Sawada

Eiichi Omata

Mitsuo Otsuki

Masahide Kohno

Osamu Nakada

Shinichi Sawada

Chung Keung Ho

Cheung Kwan Lau

Shiho Kurokawa

Robert Kneller

Reshmi Mukerji

Tomonori Nochi

Kristopher Genschmer

The present invention provides D39-derived mutant PspA that does not undergo deamination and maintains stability as a molecule even around neutral pH range. Specifically, the present invention relates to a protein of the following (a) or (b):

Pneumococcal surface proteins

The present invention provides an antibody to a fibrosis-related molecule and medical application thereof. The antibody of the present invention is an antibody that binds to CHL1 protein and an antibody that neutralizes the binding of the CHL1 protein to a fibroblast.

Antibody to fibrosis-related molecule and medical application thereof

The present embodiments provide compositions and methods related to novel recombinant protein immunogens, comprising specific portions of alpha helical domains (aHD) and proline rich regions (PRD) of pneumococcal surface protein A (PspA), which portions are linked to provide aHD-PRD constructs. The aHD and PRD proteins constituting the aHD-PRD constructs are selected to maximize cross-reactivity and provide protection against a broad spectrum of pneumococcal serotypes. Immunogenic compositions, including vaccines, comprising at least one aHD PRD construct may also include a non-linked aHD portion. Also provided are recombinant nucleic acid molecules that encode aHD-PRD constructs, vectors and recombinant host cells containing such molecules, aHD-PRD expression products, use of such nucleic acid molecules to express aHD-PRD constructs by recombinant techniques, and use of the expression products to elicit an immune or protective response against pneumococcal disease in a suitable host.

Pneumococcal vaccine combining selected alpha helical domains and proline rich domains of pneumococcal surface protein A

The present invention provides a nanogel nasal vaccine that induces cell-mediated immunity. The present invention relates to a vaccine preparation comprising a complex of a nanogel, a vaccine antigen, and an adjuvant, wherein the vaccine preparation can efficiently induce the cell-mediated immunity, and can also induce a systemic and mucosal immune response.

Intranasal vaccine that induces cellular immunity

An antibody is provided that inhibits infection of cells with a norovirus. The antibody is a nanoantibody comprising a polypeptide described in (a), (b), or (c), and inhibiting infection of intestinal cells with HuNoV GII.4: (a) a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13; (b) a polypeptide consisting of an amino acid sequence comprising a substitution, deletion, insertion and/or addition of one or several amino acids with respect to the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13; and (c) a polypeptide consisting of an amino acid sequence having a sequence identity of 80% or more to the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9, or SEQ ID NO: 13.

Norovirus antibody

A magnetic field detection device includes a magnetic field detection element, a modulation coil, and a demodulator. The magnetic field detection element has a sensitivity axis in a first direction. The modulation coil is configured to apply, to the magnetic field detection element, an alternating current magnetic field having a first frequency and a component in a second direction, the second direction being orthogonal to the first direction. The demodulator is configured to demodulate an output signal having the first frequency and outputted from the magnetic field detection element, and detect, on a basis of an amplitude of the output signal, an intensity of a measurement magnetic field to be received by the magnetic field detection element.

Magnetic field detection device and method of detecting magnetic field

A magnetic field detection device includes a magnetism detection element, a modulator, and a demodulator. The magnetism detection element has a sensitivity axis along a first direction. The modulator is configured to impart a spin torque to the magnetism detection element. The spin torque has a rotational force and oscillates at a first frequency. The rotational force is exerted on a plane including the first direction and a second direction orthogonal to the first direction. The demodulator is configured to demodulate an output signal received from the magnetism detection element and to detect an intensity of a measurement target magnetic field exerted on the magnetism detection element on the basis of an amplitude of the output signal. The output signal has the first frequency.

The present invention provides a nasal vaccine for, and a production method therefor. This nasal vaccine formulation for primates includes a complex of PspA, i.e. the vaccine antigen, and a nanogel in which hydrophobic cholesterol is added, as side chains, to pullulan having amino groups. Furthermore, the present invention provides a production method for the nasal vaccine formulation for primates.

[object Object]

Using a thermally assisted magnetic recording head, reference signals are recorded into a magnetic recording medium; reproduction signal intensity of the reference signals is measured in a state where the thermally assisted magnetic head has been moved in the track width direction from the track width center of the track where the reference signals are recorded; a mean signal output of each sector in the track where the reference signals are recorded is calculated from the measurement results of the reproduction signal intensity of the reference signals; and the recording characteristics of a thermally assisted magnetic head are evaluated based upon the mean signal output of the sectors.

Method of assessing recording characteristics of thermally assisted magnetic head

A mucosal vaccine for the prevention or treatment of microbial infections is described that is capable of inducing vaccine antigen-specific immune responses in an organism without the addition of a mucosal adjuvant. The mucosal vaccine comprises a composite of a nanogel comprising a hydrophilic polysaccharide having a cationic functional group and a hydrophobic cholesterol added thereto as a side chain and a vaccine antigen. The vaccine is administered via a mucosal route.

Mucosal vaccine using cationic nanogel

A magnetic disk device includes: a recording medium provided with a plurality of write tracks; a magnetic write head including a magnetic pole, side shields, and a leading shield, a distance from the magnetic pole to each of the side shields being maintained to be uniform with a gap layer therebetween, and a distance from the magnetic pole to the leading shield being maintained to be uniform with a gap layer therebetween; and a control section rotating the recording medium, and allowing magnetic information to be recorded on the recording medium while allowing the magnetic write head to travel in a direction from an inner write track toward an outer write track or in a direction from the outer write track toward the inner write track, across write tracks in the recording medium. With such a configuration, format efficiency may be improved, and a width of an erase band on a magnetic disk may be minimized. Therefore, surface recording density of a recording medium may be improved without reducing an effective write track width.

Magnetic recording device and magnetic recording method

In exemplary embodiments, first and second parameters are obtained for each of different temperatures of the magnetic recording layer. The absolute value of the first parameter for each magnetic grain has a minimum value when the temperature of each magnetic grain reaches a predetermined temperature that increases as the Curie temperature increases, and decreases as the Curie temperature decreases. The second parameter is related to the standard deviation of the coercivity distribution of the magnetic grains divided by the coercivity of the magnetic recording layer. The method calculates a value where the absolute measurement value of the first parameter has a minimum value and the temperature of the magnetic recording layer at which the standard deviation of the coercivity distribution of the magnetic grains divided by the coercivity of the magnetic recording layer has a maximum value.

Method of estimating curie temperature distribution in a magnetic recording layer

A measurement method of a magnetic field gradient of a recording magnetic field generated by a magnetic head in a recording medium includes a step of locally heating the recording medium in a nonmagnetic field state where a magnetic field is not applied to the recording medium at all and measuring a temperature gradient of the recording medium in the nonmagnetic field state, a step of locally heating the recording medium in a recording magnetic field application state where the recording magnetic field is applied to the recording medium and measuring a temperature gradient of the recording medium in the recording magnetic field application state, and a step of calculating a magnetic field gradient of the recording magnetic field based on the temperature gradient of the recording medium in the nonmagnetic field state and the temperature gradient of the recording medium in the recording magnetic field application state.

Method for measurement of magnetic field gradient of recording magnetic field generated by magnetic head

A magnetic head slider includes a near-field light generator, an incorporated heater is activated to thermally-expand the magnetic head slider so that a first protrusion is generated on the air bearing surface, and a second protrusion protruding from the first protrusion is generated by a thermal expansion of the near-field light generator. A standard signal is written to a recording medium with a predetermined magnetization. A relation between a residual magnetization of the standard signal and a power of the heater is obtained by lowering the magnetization of the standard signal by heating the recording medium with the near-field light while light output of laser light is maintained to be constant and the power of the heater is varied. Further, a relation between the first spacing and the residual magnetization is obtained. A value of the first spacing is obtained as a protrusion height of the second protrusion from the first protrusion when the second protrusion contacts the recording medium, the value of the first spacing being determined where an absolute value of a change rate of the residual magnetization is less than a predetermined standard value.

Method for detecting protrusion height of magnetic head slider having thermally assisted head

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Tokyo, Japan

Hiroshi Kiyono