Fuji Photo Film Company, Limited

Fujifilm Corporation

Other

Fuji Immunopharmaceuticals Corp.

Schering Aktiengesellschaft

Ihara, Masataka

Hiroshi Kitaguchi

Masatoshi Kato

Kozo Sato

Masaaki Tsukase

Kazuhiro Aikawa

Masashi Takeuchi

Masayuki Kawakami

Hideki Naito

Mitsunori Ono

Hiroyuki Hirai

Naoyuki Nishikawa

Isamu Itoh

Hideto Mori

Tadayoshi Kokubo

Yasushi Nozawa

Ryoichi Nemori

Kazunobu Takahashi

Hideaki Satoh

Masataka Ihara

Khanitha Pudhom

Kiyosei Takasu

Takeshi Takahashi

Stephen D Gillies

Masato Satomura

Hiroshi Kawamoto

Tadashi Inaba

Masanobu Takashima

Hiroshi Takeuchi

Kin-Ming Lo

Yoshihisa Tsukada

Shinsaku Fujita

Yumiko Wada

Tamio Mizukami

Itsuo Fujiwara

Tatsuya Tamaoki

Satoru Sawada

Ichiro Azuma

Yoshiyuki Yonetani

Kai Licha

Naoki Asanuma

Yaming Wu

Masayoshi Kojima

Shun-ichi Ikeda

Shigeru Yamazaki

Hiroyuki Komazawa

Tomohiro Ogawa

Atsushi Orikasa

Ikuo Saiki

Hiroaki Eguchi

Yuko Kanda

Yumiko Jimbo

Tadahiko Izushi

Hai-jian Xu

Christin Perlitz

Masasi Takeuchi

Natsuko Tsuda

Kanitha Pudhom

The present invention is to provide a medicinal composition for preventing or treating parasitic protozoan infections, having a high selective toxicity against parasitic protozoan infection, and a superior preventive or treating effect. A medicinal composition for preventing or treating parasitic protozoan infections comprises a compound shown by the following general formula (1) as an active ingredient (wherein R represents an alkyl group, aryl group or heterocyclic group; A and B each independently represents a 5- or 6-membered ring containing at least one hetero atom, or a condensation ring wherein 1 or more 3- to 8-membered ring is condensed thereto; Y represents S, O, Se, or &#x2014;NR&#x2014; (Rrepresents an alkyl group, aryl group or heterocyclic group); L, L, L, Land Leach independently represents a methine group; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0; p and q each represents an integer of 0 to 3, wherein the sum of p and q is 1 or more, and 6 or less).

Medicinal composition for prevention or treatment of parasitic protozoan infection

The present invention is to provide an anti-trypanosomiasis agent having a high selective toxicity, and high preventing or treating effect against trypanosomiasis, comprising a compound shown by the following general formula (1) as an active ingredient (wherein Rand Reach independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, Calkyl group, Calkoxy group, Caryl group, Caryloxy group, Calkoxycarbonyl group or Calkylaminocarbonyl group, and may be bound to each other; R, R, and Reach independently represents a Calkyl group or Caryl group; Rand Reach independently represents a hydrogen atom, halogen atom, hydroxyl group, oxygen atom, Calkyl group, Calkoxy group, Caryl group, Caryloxy group, or Calkoxycarbonyl group, and may be bound to each other; Y and Z each independently represents an atom group necessary to form a 5- or 6-membered heterocycle; m and n each represent 0 or 1; Q represents a physiologically acceptable anion; k represents an integer of 0 to 2, necessary to make the electric charge of the whole molecule 0).

Anti-trypanosomiasis agent

A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R, R, and Rrepresent a C-Calkyl group or the like; R, R, R, R, R, R, R, and Rrepresent a hydrogen atom, a C-Calkyl group, an aryl group or the like; Xand Xrepresent a C-Calkyl group or an aryl group and Xand Xin total have 0 to 4 carboxyl groups; m, m, and mrepresents 0 or 1; Lto Lindependently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.

Near infrared fluorescent contrast agent and method for fluorescence imaging

A compound represented by the following general formula (IA) or a salt thereof: wherein Arrepresents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Arrepresents an aryl group having at least one iodine atom as a substituent; Land Lindependently represent a divalent bridging group of which main chain contains 6 or more carbon atoms; Lrepresents a single bond or a divalent bridging group of which main chain contains 1 to 6 carbon atoms and one oxygen atom; X represents a functional group containing at least one heteroatom, provided that, when Lis a single bond, X represents a functional group other than hydroxyl group. The compound can be used as a membrane component of liposomes, and the liposomes can be used as a contrast medium for X-ray radiography.

Glycerol ester derivative

A compound represented by the following general formula (I) or a salt thereof: wherein Arand Arindependently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; Land Lindependently represent a divalent bridging group of which main chain consists of 7 or more atoms at least one of which is a heteroatom; and X represents &#x2014;CH(OH)&#x2014; or &#x2014;CO&#x2014;, which is suitable for an iodine-containing contrast medium containing liposomes.

1,3-glyceride compound having two iodophenyl groups

A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an X-ray contrast medium containing the liposome for use in radiography of a vascular disease and the like.

Liposome containing hydrophobic iodine compound

A liposome containing a hydrophobic iodine compound represented by the following general formula (I) as a membrane component:R&#x2014;CO&#x2014;Rwherein Rrepresents a substituted or unsubstituted 2,3,5-triiodophenyl group or a substituted or unsubstituted 3,4,5-triiodophenyl group; and Rrepresents a hydrocarbon group having 10 or more carbon atoms, and an X-ray contrast medium, which comprises said liposome which is used for radiography of a vascular disease.

Liposome containing hydrophobic iodine compound and X-ray contrast medium for radiograph comprising the liposome

A compound represented by the following formula (I) or a salt thereof:wherein Rand Rrepresent an alkyl group or an aryl group; Rto Rrepresent hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, a halogen atom, cyano group, carboxyl group or sulfo group; Xand Xrepresent an alkyl group having 1 to 15 carbon atoms or an aryl group, and the total number of carboxyl groups existing in Xand Xis 4 or less; mto mrepresents 0 or 1; Lto Lrepresent a methine group; M represents hydrogen atom, a metal or a quaternary ammonium salt; Y represents nonmetallic elements required to form a 5- to 10-membered heterocyclic ring; and n represents an integer of 1 to 7 required to neutralize charge, which is useful for manufacture of silver halide photographic light-sensitive materials.

Cyanine dyes

Bisaryl compound and medicament for cancer treatment comprising the same

Bis-azo compounds with 2,3-dichlorobenzoyl group

A method for inhibiting retroviral infection in a subject comprising administering to said subject a therapeutically effective amount of a naphthalenesulfonic acid compound or a pharmaceutically acceptable salt thereof, as herein defined.

Method for inhibiting retroviral infection by administering a

A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;

Tumor metastasis inhibiting compounds and methods

A peptide derivative amphiphatic compound or N-terminal salt thereof represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 each represents a straight-chain or branched alkyl or acyl group having 8 to 24 carbon atoms optionally having a substituent or an unsaturated group; X represents --O--or --NH--; R.sup.3n and R.sup.3(n+1) each represents an .alpha.--amino acid side chain; n is an integer of from 0 to 5; the compound may be a racemic compound or an optically active compound when the compound has an asymmetric carbon atom; and the N-terminal salt of the compound optionally forms with an acid component; an intermediate thereof, a liposome comprising said peptide derivative amphiphatic compound and a film consisting of a monolayer or multilayers comprising the peptide derivative amphiphatic compound are disclosed.

Peptide derivative amphiphatic compound, intermediate thereof and

An amphipathic compound, which includes a succinic acid moiety and an amino acid moiety and is designed so as to form a stable unilayer liposome, and a negatively charged liposome comprising said amphipathic compound as a membrane-component are disclosed. The amphipathic compound of the present invention gives liposomes which minimize the leakage of a drug encapsulated therein and scarcely undergo association, aggregation or precipitation.

Amphipathic compound and liposome comprising the same

An image is formed in a photographic element by a process comprising a step of heating a heat-developable photosensitive material in the presence of a specific compound which typically releases a phenylmercaptotetrazole having a substituted benzene ring and serving as a development retarder.

Image forming process including heating step

Growing community of inventors

Kanagawa, Japan

Hiroshi Kitaguchi